CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017873
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ataxin-7 
Protein Synonyms/Alias
 Spinocerebellar ataxia type 7 protein homolog 
Gene Name
 Atxn7 
Gene Synonyms/Alias
 Sca7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
222LPLRGNMKPMHPVQQacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX- dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). 
Sequence Annotation
 DOMAIN 320 387 SCA7.
 CROSSLNK 243 243 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 867 AA 
Protein Sequence
MSERAADDVR GEPRRAAGGA AAARQQQQQP QPLQPQRQHP PLRRPRAEDG GTGDTTTSAA 60
AMATVGERRP LPSPEAMLGQ SWNLWVEASK LPGKDGTELD ESFKEFGKNR EVMGLCREDM 120
PIFGLCPAHD DFYLVVCNDC NQVVKPQAFQ SHYERRHSSS SKPALAVPHT SVFSLLPSLS 180
KSKGSGAGGS SRPPSGGVLC ASSSSKLLRL PKEKLPLRGN MKPMHPVQQI KVPHGRVMTP 240
SVKVEKMHPK MDGTLLKSTV GPACPATMSS AVKPGLNCPS IPKPTLPSPG QILNGKGLPA 300
MPTLEKKSED SSNNRKFLNK RLSEREFDPD IHCGVIDLDT KKPCTRSLTC KTHSLTQRRA 360
VQGRRKRFDV LLAEHKNKAR EKELIRHDSQ QVPHPLRDPH PTPPRTPQEP QLPAESKPFL 420
ASKPKPQTPS LPRPPGCPAQ QGGSTPIDPP PGQESPHPPL PATEPASRLS SEEGEGDDRE 480
ESVEKLDCHY SGRHPQPASF CTFGSRQIGR GYYVFDSRWN RLRCALNLMV EKHLNAQLWK 540
KIPPVPCTTS PVSARVPHRT NSVPTSQGGI SYLAATTVSA PPVLLSSTCI SPNSKSVPAH 600
GTTLNAQPAG SGAMDPVCSV QSRQVSASSS PPSTPSGLSS VPSSPLSRKP QKWKPSKSIR 660
PKESSALSTN CHNASSSTSG GSGKKRKNSS PLLVPSSSSS SSSSSSSSHS VNSFRKNCVA 720
HSGTPYLSTA PSSHSIGLNC VTNKTHSVSL RHEQAGRGPA GVSSAEPIKR MSVMVNSSDS 780
TLSLGPFIHQ ASELPVNPHS HTPLDKLIGK KRKCSPGSST VGNSGSKPTK VAKLPAMNNV 840
HMKHTGNISG AQGLTNNSLL HQPKARP 867 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0016578; P:histone deubiquitination; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:MGI.
 GO:0042326; P:negative regulation of phosphorylation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR013243; SCA7_dom.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF08313; SCA7 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS51505; SCA7 
PRINTS