UniProt Accession

 RCL1_HUMAN; Q9Y2P8; D3DRI2; Q5VYW9; Q9H9D0; Q9NY00; Q9P044 

Genbank Protein ID

 AJ276894; AK022904; AL158147; AL353151; AL353151; AL158147; CH471071; CH471071; BC001025; AF067172; AF161456 

Genbank Nucleotide ID

 CAB89811.1; BAB14300.1; CAH70320.1; CAH70320.1; CAH72285.1; CAH72285.1; EAW58776.1; EAW58777.1; AAH01025.1; AAD32456.1; AAF29016.1 

Protein Name

 RNA 3'-terminal phosphate cyclase-like protein 

Protein Synonyms/Alias

  

Gene Name

 RCL1 

Gene Synonyms/Alias

 RNAC; RPC2; RPCL1; RTC2; HSPC338 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
133	DPSVDVLKATALPLL	ubiquitination	[1, 2, 3, 4, 5]
141	ATALPLLKQFGIDGE	ubiquitination	[1, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; NAS:UniProtKB.
 GO:0003963; F:RNA-3'-phosphate cyclase activity; NAS:UniProtKB.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
 GO:0006396; P:RNA processing; IEA:InterPro. 

Interpro

 IPR013791; RNA3'-term_phos_cycl_insert.
 IPR023797; RNA3'_phos_cyclase_dom.
 IPR000228; RNA3'_term_phos_cyc.
 IPR016443; RNA3'_term_phos_cyc_type_2.
 IPR020719; RNA3'_term_phos_cycl-like_CS.
 IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b. 

Pfam

 PF01137; RTC
 PF05189; RTC_insert 

SMART

  

PROSITE

 PS01287; RTC 

PRINTS