CPLM-018643

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018643

UniProt Accession

Genbank Protein ID

AY823670; AY289210; AY293564; AY297108; AK034037; AK045577; AK047368; AK147913; CH466529; CH466529; BC125305; AJ297318; AF503616

Genbank Nucleotide ID

AAX39497.1; AAP41202.1; AAP50246.1; AAP51160.1; BAC28554.1; BAC32421.1; BAC33038.1; BAE28224.1; EDL19225.1; EDL19226.1; AAI25306.1; CAC29245.1; AAM21146.1

Protein Name

Gap junction gamma-3 protein

Protein Synonyms/Alias

Connexin-29; Cx29; Gap junction epsilon-1 protein

Gene Name

Gjc3

Gene Synonyms/Alias

Cx29; Gje1

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
254	SESSVRSKDTTDELS	ubiquitination	[1]
266	ELSVVEAKEPF****	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity).

Sequence Annotation

Keyword

Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

269 AA

Protein Sequence

MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS GPGVFGNDEN 60
EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA IYVAFTLYHV IGYWEVPGKE 120
NKEQETQISK GDHSKDVSGA KSLKLLWAYV AHLGVRLALE GAALGVQYNL YGFKMSSTFI 180
CREDPCIGST TCFQSHPSEK TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF 240
LKKLPTSESS VRSKDTTDEL SVVEAKEPF 269

Gene Ontology

GO:0005922; C:connexon complex; IEA:InterPro.
GO:0005921; C:gap junction; ISA:MGI.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0043209; C:myelin sheath; IDA:MGI.
GO:0005243; F:gap junction channel activity; ISA:MGI.
GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO:0007267; P:cell-cell signaling; ISA:MGI.
GO:0042552; P:myelination; IMP:MGI.
GO:0007605; P:sensory perception of sound; IMP:MGI.

Interpro

IPR000500; Connexin.
IPR019570; Connexin_CCC.
IPR017990; Connexin_CS.
IPR013092; Connexin_N.

Pfam

PF00029; Connexin
PF10582; Connexin_CCC

SMART

SM01089; Connexin_CCC

PROSITE

PS00407; CONNEXINS_1
PS00408; CONNEXINS_2

PRINTS

PR00206; CONNEXIN.