CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028666
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transient receptor potential cation channel subfamily M member 7 
Protein Synonyms/Alias
  
Gene Name
 Trpm7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
481LEELYNTKQGPTNPMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1862 AA 
Protein Sequence
MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM 60
KYSDVKLGEH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEII 120
LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV 180
AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN 240
LHSHFILVDD GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV 300
LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI KKTFNFGQSE 360
AVHLFQTMME CMKKKELITV FHIGSEDHQD IDVAILTALL KGTNASAFDQ LILTLAWDRV 420
DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVSFVKLLIE NGVSMHKFLT IPRLEELYNT 480
KQGPTNPMLF HLIRDVKQGN LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL 540
GGNNRRSGRN TSSSTPQLRK SHETFGNRAD KKEKMRHNHF IKTAQPYRPK MDASMEEGKK 600
KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA KALVACKIYR 660
SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ DETMAMKLLT YELKNWSNST 720
CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR LNMRKNSWYK VILSILVPPA ILMLEYKTKA 780
EMSHIPQSQD AHQMTMEDSE NNFHNITEEI PMEVFKEVKI LDSSDGKNEM EIHIKSKKLP 840
ITRKFYAFYH APIVKFWFNT LAYLGFLMLY TFVVLVKMEQ LPSVQEWIVI AYIFTYAIEK 900
VREVFMSEAG KISQKIKVWF SDYFNVSDTI AIISFFVGFG LRFGAKWNYI NAYDNHVFVA 960
GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM FYIVVIMALV LLSFGVPRKA 1020
ILYPHEEPSW SLAKDIVFHP YWMIFGEVYA YEIDVCANDS TLPTICGPGT WLTPFLQAVY 1080
LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS 1140
LFCCVCKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFDEKDDKFN SGSEERIRVT 1200
FERVEQMSIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT AQKASEASKV 1260
HNEITRELSI SKHLAQNLID DVPVRPLWKK PSAVNTLSSS LPQGDRESNN PFLCNIFMKD 1320
EKDPQYNLFG QDLPVIPQRK EFNIPEAGSS CGALFPSAVS PPELRQRRHG VEMLKIFNKN 1380
QKLGSSPNSS PHMSSPPTKF SVSTPSQPSC KSHLESTTKD QEPIFYKAAE GDNIEFGAFV 1440
GHRDSMDLQR FKETSNKIRE LLSNDTPENT LKHVGAAGYS ECCKTSTSLH SVQESCSRRA 1500
STEDSPEVDS KAALLPDWLR DRPSNREMPS EGGTLNGLAS PFKPVLDTNY YYSAVERNNL 1560
MRLSQSIPFV PVPPRGEPVT VYRLEESSPS ILNNSMSSWS QLGLCAKIEF LSKEEMGGGL 1620
RRAVKVLCTW SEHDILKSGH LYIIKSFLPE VINTWSSIYK EDTVLHLCLR EIQQQRAAQK 1680
LTFAFNQMKP KSIPYSPRFL EVFLLYCHSA GQWFAVEECM TGEFRKYNNN NGDEIIPTNT 1740
LEEIMLAFSH WTYEYTRGEL LVLDLQGVGE NLTDPSVIKA EEKRSCDMVF GPANLGEDAI 1800
KNFRAKHHCN SCCRKLKLPD LKRNDYTPDK IIFPQDESSD LNLQSGNSTK ESEATNSVRL 1860
ML 1862 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005262; F:calcium channel activity; IDA:MGI.
 GO:0016301; F:kinase activity; IDA:MGI.
 GO:0017022; F:myosin binding; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0031032; P:actomyosin structure organization; IDA:MGI.
 GO:0016340; P:calcium-dependent cell-matrix adhesion; IDA:MGI.
 GO:0046777; P:protein autophosphorylation; IDA:MGI. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR011009; Kinase-like_dom.
 IPR004166; MHCK_EF2_kinase. 
Pfam
 PF02816; Alpha_kinase
 PF00520; Ion_trans 
SMART
 SM00811; Alpha_kinase 
PROSITE
 PS51158; ALPHA_KINASE 
PRINTS