UniProt Accession

 ZDHC5_HUMAN; Q9C0B5; Q2TGF0; Q6ZMF0; Q8TAK8; Q9H923; Q9UFI7 

Genbank Protein ID

 AB051535; AY894889; AK023130; AK172807; CH471076; BC026967; AL117662 

Genbank Nucleotide ID

 BAB21839.1; AAX73368.1; BAB14420.1; BAD18778.1; EAW73771.1; AAH26967.1; CAB56033.1 

Protein Name

 Palmitoyltransferase ZDHHC5 

Protein Synonyms/Alias

 Zinc finger DHHC domain-containing protein 5; DHHC-5; Zinc finger protein 375 

Gene Name

 ZDHHC5 

Gene Synonyms/Alias

 KIAA1748; ZNF375 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	LYKTVEIKGIQVRMK	ubiquitination	[1, 2]
224	TNEQVTGKFRGGVNP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity). 

Sequence Annotation

 ZN_FING 104 154 DHHC-type.
 ACT_SITE 134 134 S-palmitoyl cysteine intermediate (By
 MOD_RES 91 91 Phosphotyrosine (By similarity).
 MOD_RES 247 247 Phosphoserine (By similarity).
 MOD_RES 296 296 Phosphoserine.
 MOD_RES 299 299 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 348 348 Phosphothreonine.
 MOD_RES 380 380 Phosphoserine.
 MOD_RES 385 385 Phosphothreonine (By similarity).
 MOD_RES 409 409 Phosphoserine.
 MOD_RES 432 432 Phosphoserine.
 MOD_RES 436 436 Phosphothreonine.
 MOD_RES 529 529 Phosphoserine (By similarity).
 MOD_RES 554 554 Phosphoserine.
 MOD_RES 621 621 Phosphoserine.
 MOD_RES 659 659 Phosphothreonine.
 MOD_RES 684 684 Phosphoserine.
 MOD_RES 694 694 Phosphoserine.  

Keyword

 Acyltransferase; Alternative splicing; Cell membrane; Complete proteome; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 715 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016409; F:palmitoyltransferase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0018345; P:protein palmitoylation; IDA:MGI. 

Interpro

 IPR001594; Znf_DHHC_palmitoyltrfase. 

Pfam

 PF01529; zf-DHHC 

SMART

  

PROSITE

 PS50216; ZF_DHHC 

PRINTS