UniProt Accession

 VAPA_HUMAN; Q9P0L0; A6NDZ0; D3DUI3; O75453; Q5U0E7; Q9UBZ2 

Genbank Protein ID

 AF044670; AF154847; AC006238; CH471113; CH471113; BC002992; BG488667; AF057358; AF086627; BT019618 

Genbank Nucleotide ID

 AAD09742.1; AAF72105.1; EAX01591.1; EAX01592.1; AAH02992.2; AAC26508.1; AAD13576.1; AAV38424.1 

Protein Name

 Vesicle-associated membrane protein-associated protein A 

Protein Synonyms/Alias

 VAMP-A; VAMP-associated protein A; VAP-A; 33 kDa VAMP-associated protein; VAP-33 

Gene Name

 VAPA 

Gene Synonyms/Alias

 VAP33 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	PPTDLKFKGPFTDVV	ubiquitination	[1]
233	RLQGEMMKLSEENRH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May play a role in vesicle trafficking. 

Sequence Annotation

 DOMAIN 14 131 MSP.
 MOD_RES 125 125 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0031982; C:vesicle; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0008219; P:cell death; IMP:UniProtKB.
 GO:0006944; P:cellular membrane fusion; TAS:ProtInc.
 GO:0031175; P:neuron projection development; IMP:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0070972; P:protein localization to endoplasmic reticulum; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome. 

Interpro

 IPR000535; Major_sperm.
 IPR008962; PapD-like.
 IPR016763; Vesicle-associated_membrane. 

Pfam

 PF00635; Motile_Sperm 

SMART

  

PROSITE

 PS50202; MSP 

PRINTS