CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor tyrosine-protein kinase erbB-3 
Protein Synonyms/Alias
 Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3 
Gene Name
 Erbb3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
693EPLDPSEKANKVLARubiquitination[1]
734IPEGESIKIPVCIKVubiquitination[1]
862DLLPPDDKQLLHSEAubiquitination[1]
924EIPDLLEKGERLAQPubiquitination[1]
1333WHSRLFPKANAQRI*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5 (By similarity). 
Sequence Annotation
 DOMAIN 707 964 Protein kinase.
 NP_BIND 713 721 ATP (By similarity).
 NP_BIND 786 788 ATP (By similarity).
 NP_BIND 832 837 ATP (By similarity).
 ACT_SITE 832 832 Proton acceptor (By similarity).
 BINDING 740 740 ATP (By similarity).
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 250 250 N-linked (GlcNAc...) (Potential).
 CARBOHYD 353 353 N-linked (GlcNAc...) (Potential).
 CARBOHYD 408 408 N-linked (GlcNAc...) (Potential).
 CARBOHYD 414 414 N-linked (GlcNAc...) (Potential).
 CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
 CARBOHYD 469 469 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...) (Potential).
 CARBOHYD 566 566 N-linked (GlcNAc...) (Potential).
 CARBOHYD 616 616 N-linked (GlcNAc...) (Potential).
 DISULFID 186 194 By similarity.
 DISULFID 190 202 By similarity.
 DISULFID 210 218 By similarity.
 DISULFID 214 226 By similarity.
 DISULFID 227 235 By similarity.
 DISULFID 231 243 By similarity.
 DISULFID 246 255 By similarity.
 DISULFID 259 286 By similarity.
 DISULFID 290 301 By similarity.
 DISULFID 305 320 By similarity.
 DISULFID 323 327 By similarity.
 DISULFID 500 509 By similarity.
 DISULFID 504 517 By similarity.
 DISULFID 520 529 By similarity.
 DISULFID 533 549 By similarity.
 DISULFID 552 565 By similarity.
 DISULFID 556 573 By similarity.
 DISULFID 576 585 By similarity.
 DISULFID 589 610 By similarity.
 DISULFID 613 621 By similarity.
 DISULFID 617 629 By similarity.  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1339 AA 
Protein Sequence
MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 60
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 120
LNYNTNSSHA LRQLRFTQLT EILLGGVYIE KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG 180
GNCPPCHEVC KGRCWGPGPE DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 240
TDCFACRHFN DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 300
CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 360
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPAEE 480
RLDIKYNRPL GECVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP 540
REFVHEAHCF SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL TVIFLILGGS 660
FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 720
VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 780
LQLVTQYLPL GSLLDHVRQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 840
KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 960
NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD AELEPDLDLD LDVEVEEEGL 1020
ATTLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSNLG EACLDSAVLG GREQFSRPIS 1080
LHPIPRGRQT SESSEGHVTG SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 1140
TPLSPPGLEE EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200
RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 1260
NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP HVRYARLKTL RSLEATDSAF 1320
DNPDYWHSRL FPKANAQRI 1339 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0030296; F:protein tyrosine kinase activator activity; IEA:Compara.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; IEA:InterPro.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0021545; P:cranial nerve development; IMP:MGI.
 GO:0003197; P:endocardial cushion development; IMP:MGI.
 GO:0007162; P:negative regulation of cell adhesion; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0051048; P:negative regulation of secretion; IEA:Compara.
 GO:0009968; P:negative regulation of signal transduction; IEA:Compara.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0014037; P:Schwann cell differentiation; IMP:MGI.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt. 
Pfam
 PF00757; Furin-like
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 
SMART
 SM00261; FU
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.