CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Hook homolog 3 
Protein Synonyms/Alias
 mHK3 
Gene Name
 Hook3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
421RTERDSLKETIEELRubiquitination[1]
488QEDSDNEKIALLQSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. 
Sequence Annotation
 REGION 1 164 Sufficient for interaction with
 REGION 450 671 Sufficient for interaction with IIGP1.
 REGION 553 718 Required for association with Golgi (By
 MOD_RES 238 238 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Microtubule; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 718 AA 
Protein Sequence
MFNVESVERV ELCESLLTWI QTFNVDAPCQ TAEDLTNGVV MSQVLQKIDP VYFDDNWLNR 60
IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL PDVNLIGEHS DAAELGRMLQ 120
LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSAGHDA YVDLDRQLKK 180
TTEELNEALS AKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QILMERLNQS DSIEDPNSPA 240
GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK 300
DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK 360
ANAARGQLET YKRQVVELQN RLSDESKKAD KLDFEYKRLK EKVDGLQKEK DRLRTERDSL 420
KETIEELRCV QAQEGQLTTQ GLMPLGSQES SDSLAAEIVT PEIREKLIRL QHENKMLKLN 480
QEDSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED 540
SVLLKKKLEE HLEKLHEANN ELQKKRAIIE DLEPRFNNSS LRIEELQEAL RKKEEEMKQM 600
EERYKKYLEK AKSVIRTLDP KQNQGAAPEI QALKNQLQER DRLFHSLEKE YEKTKSQRDM 660
EEKYIVSAWY NMGMTLHKKA AEDRLASTGS GQSFLARQRQ ATSTRRSYPG HVQPATAR 718 
Gene Ontology
 GO:0034451; C:centriolar satellite; IDA:MGI.
 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0070695; C:FHF complex; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0030897; C:HOPS complex; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0000242; C:pericentriolar material; IDA:BHF-UCL.
 GO:0031122; P:cytoplasmic microtubule organization; IEA:Compara.
 GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
 GO:0007032; P:endosome organization; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
 GO:0051645; P:Golgi localization; IEA:Compara.
 GO:0022027; P:interkinetic nuclear migration; IMP:BHF-UCL.
 GO:0007040; P:lysosome organization; ISS:UniProtKB.
 GO:0034454; P:microtubule anchoring at centrosome; IMP:MGI.
 GO:0050768; P:negative regulation of neurogenesis; IMP:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; IMP:MGI.
 GO:0071539; P:protein localization to centrosome; IMP:BHF-UCL.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR008636; HOOK/CCDC88. 
Pfam
 PF05622; HOOK 
SMART
  
PROSITE
  
PRINTS