| Tag | Content |
|---|
| CPLM ID | CPLM-011180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein VMS1 |
Protein Synonyms/Alias | VCP/CDC48-associated mitochondrial stress-responsive protein 1 |
Gene Name | VMS1 |
Gene Synonyms/Alias | YDR049W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 592 | AERGPGKKLTNIPSI | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability. |
Sequence Annotation | REPEAT 470 500 ANK 1.
REPEAT 504 530 ANK 2.
ZN_FING 72 96 C2H2-type. |
Keyword | ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Metal-binding; Mitochondrion; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 632 AA |
Protein Sequence | MNSQKASKMT GSLKKNDLYI FDLSEQLLNS LKLMSFDSTL REVEVEKTSD NDRNKESGDL 60
QIARKKVTSN VMRCSVCQMS FDSRNEQKAH YQTDYHLMNV KRNLRGLDIL SVEEFDALIS 120
KEHGIKSEDE NSGGEQTSSD HEESEEASDR DPDLQTNNYM ETIIENDLQK LGFQKDESDA 180
ISHINTQSPY IYFKSKYLQK NEVLAIYKSL FNKRSLSNPN EALTFWNSQE NPMAISALFM 240
VGGGHFAGAI VSHQRLNVKG NAHKKDETLI EQAVNFLEHK TFHRYTTRRK QGGSQSAMDN 300
AKGKANSAGS ALRRYNESAL KTDIQGVLKD WEPYLSKCDN IFIRARNVSD KKIFTDNTVL 360
NKGDERIKSF PFTTNRPTVL ELKKAWCELS YLKILPKPEP LAVKETVQKL EVSNKKDEFK 420
EKQEPLLEEI QTEEIISLLK KGRAPLLISF LKKNKLDGNF RLKPESKYSL TPTMLHYASQ 480
QGMKQMALIL LSNIKCDPTI KNRLGRTAWD LNRNDDVRHA FQIARYNLGE SFTNWDETHI 540
GQPLSREQVD EINEKKKAIE NEKAEKLIKL ELEAAKEKQR FAKDAERGPG KKLTNIPSIQ 600
QQNLNSLTDE QRRRLMREQR ARAAEERMKK KY 632 |
Gene Ontology | GO:0036266; C:Cdc48p-Npl4p-Vms1p AAA ATPase complex; IDA:SGD. GO:0005829; C:cytosol; IDA:SGD. GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030433; P:ER-associated protein catabolic process; IMP:SGD. GO:0072671; P:mitochondria-associated protein catabolic process; IMP:SGD. GO:0071630; P:nucleus-associated proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |