UniProt Accession

 NUD18_HUMAN; Q6ZVK8; Q8IZ75; Q9H687 

Genbank Protein ID

 AK026147; AK124446; BC016902 

Genbank Nucleotide ID

 BAB15376.1; BAC85853.1; AAH16902.1 

Protein Name

 8-oxo-dGDP phosphatase NUDT18 

Protein Synonyms/Alias

 2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; MutT homolog 3; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18 

Gene Name

 NUDT18 

Gene Synonyms/Alias

 MTH3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	EALQREVKEEAGLHC	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. 

Sequence Annotation

 DOMAIN 37 167 Nudix hydrolase.
 MOTIF 76 97 Nudix box.
 METAL 91 91 Magnesium or manganese (By similarity).
 METAL 95 95 Magnesium or manganese (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0044717; F:8-hydroxy-dADP phosphatase activity; IDA:UniProtKB.
 GO:0044715; F:8-oxo-dGDP phosphatase activity; IDA:UniProtKB.
 GO:0044716; F:8-oxo-GDP phosphatase activity; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0046057; P:dADP catabolic process; IDA:UniProtKB.
 GO:0046067; P:dGDP catabolic process; IDA:UniProtKB.
 GO:0046712; P:GDP catabolic process; IDA:UniProtKB.
 GO:0034656; P:nucleobase-containing small molecule catabolic process; TAS:Reactome. 

Interpro

 IPR020476; Nudix_hydrolase.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR00502; NUDIXFAMILY.