| Tag | Content |
|---|
| CPLM ID | CPLM-000744 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleiotropic regulator 1 |
Protein Synonyms/Alias | |
Gene Name | PLRG1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 126 | VALPLQTKADANRTA | ubiquitination | [1] | | 311 | RIWDVRTKASVHTLS | ubiquitination | [1] | | 354 | LWDLVAGKTRVTLTN | ubiquitination | [1] | | 387 | SGSPDNIKQWKFPDG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). |
Sequence Annotation | REPEAT 202 241 WD 1.
REPEAT 244 283 WD 2.
REPEAT 286 325 WD 3.
REPEAT 328 367 WD 4.
REPEAT 370 410 WD 5.
REPEAT 411 449 WD 6.
REPEAT 460 499 WD 7.
MOD_RES 1 1 N-acetylmethionine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 514 AA |
Protein Sequence | MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGVALT ADTKIQRMPS ESAAQSLAVA 120
LPLQTKADAN RTAPSGSEYR HPGASDRPQP TAMNSIVMET GNTKNSALMA KKAPTMPKPQ 180
WHPPWKLYRV ISGHLGWVRC IAVEPGNQWF VTGSADRTIK IWDLASGKLK LSLTGHISTV 240
RGVIVSTRSP YLFSCGEDKQ VKCWDLEYNK VIRHYHGHLS AVYGLDLHPT IDVLVTCSRD 300
STARIWDVRT KASVHTLSGH TNAVATVRCQ AAEPQIITGS HDTTIRLWDL VAGKTRVTLT 360
NHKKSVRAVV LHPRHYTFAS GSPDNIKQWK FPDGSFIQNL SGHNAIINTL TVNSDGVLVS 420
GADNGTMHLW DWRTGYNFQR VHAAVQPGSL DSESGIFACA FDQSESRLLT AEADKTIKVY 480
REDDTATEET HPVSWKPEII KRKRF 505 |
Gene Ontology | GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0004871; F:signal transducer activity; TAS:ProtInc. GO:0003714; F:transcription corepressor activity; TAS:ProtInc. GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |