| Tag | Content |
|---|
| CPLM ID | CPLM-008033 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lanosterol synthase |
Protein Synonyms/Alias | 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC |
Gene Name | Lss |
Gene Synonyms/Alias | Osc |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 433 | DNNPDYQKYYRHMHK | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. |
Sequence Annotation | REPEAT 125 166 PFTB 1.
REPEAT 484 529 PFTB 2.
REPEAT 561 601 PFTB 3.
REPEAT 613 654 PFTB 4.
ACT_SITE 233 233 Proton acceptor (By similarity).
ACT_SITE 456 456 Proton donor (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Repeat; Steroid biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 733 AA |
Protein Sequence | MTEGTCLRRR GGPYKTEPAT DLTRWRLHNE LGRQRWTYYQ AEEDPGREQT GLEAHSLGLD 60
TTSYFKNLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG GPLFLLPGLL ITCHIAHIPL 120
PAGYREEMVR YLRSVQLPDG GWGLHIEDKS TVFGTALSYV SLRILGIGPD DPDLVRARNI 180
LHKKGGAVAI PSWGKFWLAV LNVYSWEGIN TLFPEMWLLP EWFPAHPSTL WCHCRQVYLP 240
MSYCYATRLS ASEDPLVQSL RQELYVEDYA SIDWPAQKNN VCPDDMYTPH SWLLHVVYGL 300
LNLYERFHST SLRKWAIQLL YEHVAADDRF TKCISIGPIS KTVNMLIRWS VDGPSSPAFQ 360
EHVSRIKDYL WLGLDGMKMQ GTNGSQTWDT SFAVQALLEA GAHRRPEFLP CLQKAHEFLR 420
LSQVPDNNPD YQKYYRHMHK GGFPFSTLDC GWIVADCTAE ALKAVLLLQE RCPSITEHVP 480
RERLYDAVAV LLSMRNSDGG FATYETKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ 540
ALRHFREYFP DHRATESRET LNQGLDFCRK KQRADGSWEG SWGVCFTYGT WFGLEAFACM 600
GHIYQNRTAC AEVAQACHFL LSRQMADGGW GEDFESCEQR RYVQSAGSQV HSTCWALLGL 660
MAVRHPDISA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS CAISYTNYRN IFPIWALGRF 720
SSLYPDNTLA GHI 733 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0000250; F:lanosterol synthase activity; IDA:RGD. GO:0006695; P:cholesterol biosynthetic process; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |