CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028873
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor 1 
Protein Synonyms/Alias
  
Gene Name
 Nfib 
Gene Synonyms/Alias
 RP24-231F12.1-003 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
317SSPTTMKKPEKPLFSacetylation[1]
320TTMKKPEKPLFSSTSacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity). 
Sequence Annotation
  
Keyword
 Activator; Complete proteome; DNA replication; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 560 AA 
Protein Sequence
MYSPICLTQD EFHPFIEALL PHVRAIAYTW FNLQARKRKY FKKHEKRMSK DEERAVKDEL 60
LSEKPEIKQK WASRLLAKLR KDIRQEYRED FVLTVTGKKH PCCVLSNPDQ KGKIRRIDCL 120
RQADKVWRLD LVMVILFKGI PLESTDGERL MKSPHCTNPA LCVQPHHITV SVKELDLFLA 180
YYVQEQDSGQ SGSPSHSDPA KNPPGYLEDS FVKSGVFNVS ELVRVSRTPI TQGTGVNFPI 240
GEIPSQPYYH DMNSGVNLQR SLSSPPSSKR PKTISIDENM EPSPTGDFYP SPNSPAAGSR 300
TWHERDQDMS SPTTMKKPEK PLFSSTSPQD SSPRLSTFPQ HHHPGIPGVA HSVISTRTPP 360
PPSPLPFPTQ AILPPAPSSY FSHPTIRYPP HLNPQDTLKN YVPSYDPSSP QTSQPNSSGQ 420
VVGKVPGHFT PVLAPSPHPS AVRPVTLTMT DTKPITTSTE AYTASGTSQA NRYVGLSPRD 480
PSFLHQQQLR ICDWTMNQNG RHLYPSTSED TLGITWQSPG TWASLVPFQV SNRTPILPAN 540
VQNYGLNIIG EPFLQAETSN 560 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0030902; P:hindbrain development; IMP:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000647; CTF/NFI.
 IPR020604; CTF/NFI_DNA-bd-dom.
 IPR019739; CTF/NFI_DNA-bd_CS.
 IPR019548; CTF/NFI_DNA-bd_N.
 IPR003619; MAD_homology1_Dwarfin-type. 
Pfam
 PF00859; CTF_NFI
 PF03165; MH1
 PF10524; NfI_DNAbd_pre-N 
SMART
 SM00523; DWA 
PROSITE
 PS00349; CTF_NFI_1
 PS51080; CTF_NFI_2 
PRINTS