| Tag | Content |
|---|
| CPLM ID | CPLM-023410 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 3 subunit A |
Protein Synonyms/Alias | eIF3a; Eukaryotic translation initiation factor 3 subunit 10 |
Gene Name | eIF3-S10 |
Gene Synonyms/Alias | CG9805 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 70 | LKKSHIAKEGLFQYR | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity). |
Sequence Annotation | DOMAIN 427 498 PCI.
MOD_RES 908 908 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1140 AA |
Protein Sequence | MARYTQRPEN ALKRANEFIE VGKPLRALDT LQEVFRNKRW NYAYSETVIE PLMFKYLYLC 60
VELKKSHIAK EGLFQYRNMF QLVNVNSLEN VIRGYLKMAE EHTEAAQAQS SAAVAVLELD 120
DLDNIATPES ILMSAVCGED AQDRSDRTIL LPWVKFLWES YCQCLELLRV NTHCEALYHD 180
IARMAFQFCL KYNRKSEFRR LCDKLRKHLE DICKSSNQTT GVSINKVETQ QLCLDTRLYL 240
LDSAIQMELW QEAYKAIEDI HGLMALSKKT PVPKTMANYY QKLAMVFSKA GNQLFHAAAL 300
LKLFQLTREL KKNLTKDDLQ RMAAHVLLAT LSIPLPSAHP EFDRFIEADK SPLEKAQKLA 360
VLLGLPQPPT RVSLIREVVR LNVPQLVSED FRNLYNWLEV DFNPLNLCKR IQSIVDFIEN 420
GPENALLTPY IQSLKDVTIM RLIRQISQVY ESIKFQRLLQ LASFCNIFEL EKLLVESVRH 480
NDMQIRIDHQ KNSIYFGTDL TESQREYRPD GPALQSMPSE QIRSQLVNMS TVLTRAVSIV 540
YPNRERDQRA KLRNQMVNHY HEIKDREHQR ILQRQKIIED RKEYIEKQNN AREEEEARRQ 600
EEESRKAKLA EQKRLEQEQE ERERKRHQNE IQAIREKSLK EKVQQISQTA HGKKMLSKLD 660
EEGIKKLDAE QIAKRESEEL QREAKELQSK LKSQEKKIDY FERAKRLEEI PLFEKYLAEK 720
QVKDKEFWEA TEKTRIENAI AERKDAVAQQ ERLKRMYPDR DEFLEALKKE RASLYVEKLK 780
KFEAALEAER KKRLADRIIR RREERRQAFL REKEEERLRK EEEIRLAQAA EERAAAEARR 840
LEREAEDEKR RAQYEKQRAK EEEAERKIKE DRDRLSRELA SERERTEKDR DTWRPRGGDR 900
PSASNGGSSE WRRAAPAASE RNDRGGERIE RGGERIERGG ERLERGGERI ERGGDRDRKD 960
NEGADSSWRV RREPDSQRAA APKDSGAPQS RDDKWRRGGE RDRDFRIDGA RRDRDDGPRR 1020
DRDDGPRRDR DDERGGFRRA DGARRTDEPQ RETGGNWRDA PRHADRETRR PAERRDRDVR 1080
ETRGDQRGSA PKEAASGGVG GNWRTAPATR EEKPAAKRDQ AQEKENKAGD DGEWTSVKRR 1140 |
Gene Ontology | GO:0005829; C:cytosol; ISS:FlyBase. GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP. GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP. GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB. GO:0003743; F:translation initiation factor activity; ISS:UniProtKB. GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP. GO:0000022; P:mitotic spindle elongation; IMP:FlyBase. GO:0006446; P:regulation of translational initiation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |