CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001489
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SUN domain-containing protein 1 
Protein Synonyms/Alias
 Protein unc-84 homolog A; Sad1/unc-84 protein-like 1 
Gene Name
 SUN1 
Gene Synonyms/Alias
 KIAA0810; UNC84A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
159LDDDGDLKGGNKAAIubiquitination[1]
195CSMLSERKDVLTAHPubiquitination[1, 2]
367DDPQDVFKPTTSRLKubiquitination[1, 2]
419ELTTLLQKLQARVDQubiquitination[1, 2]
481EKSEAIQKELEQTKQubiquitination[1]
571FSSQFVSKGDLQTMLubiquitination[1]
637LKLYSQDKTGMVDFAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). 
Sequence Annotation
 DOMAIN 649 811 SUN.
 REGION 1 138 LMNA-binding.
 REGION 209 302 SYNE2-binding.
 REGION 223 302 EMD-binding.
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 812 AA 
Protein Sequence
MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 60
TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 120
TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH 180
NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC DDCKGKRHLD AHPGRAGTLW 240
HIWACAGYFL LQILRRIGAV GQAVSRTAWS ALWLAVVAPG KAASGVFWWL GIGWYQFVTL 300
ISWLNVFLLT RCLRNICKFL VLLIPLFLLL AGLSLRGQGN FFSFLPVLNW ASMHRTQRVD 360
DPQDVFKPTT SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL RELTTLLQKL 420
QARVDQMEGG AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG KLREKSEAIQ 480
KELEQTKQKT ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD AVQERVDVQV 540
REMVKLLFSE DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT HHVSVTKQLP 600
TSEAVVSAVS EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG SILSTRCSET 660
YETKTALMSL FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS MMIHPAAFTL 720
EHIPKTLSPT GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM FQALKRPDDT 780
AFQIVELRIF SNWGHPEYTC LYRFRVHGEP VK 812 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0034993; C:SUN-KASH complex; IDA:UniProtKB.
 GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB.
 GO:0006998; P:nuclear envelope organization; IGI:MGI.
 GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IDA:UniProtKB. 
Interpro
 IPR018539; RNA-bd_mt.
 IPR012919; Sad1_UNC_C. 
Pfam
 PF09387; MRP
 PF07738; Sad1_UNC 
SMART
  
PROSITE
 PS51469; SUN 
PRINTS