CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010647
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome biogenesis protein BOP1 
Protein Synonyms/Alias
 Block of proliferation 1 protein 
Gene Name
 Bop1 
Gene Synonyms/Alias
 Kiaa0124 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MAGACGKPHMSPASacetylation[1, 2]
332KLNFLPQKFPSLRTVubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. 
Sequence Annotation
 REPEAT 397 436 WD 1.
 REPEAT 438 478 WD 2.
 REPEAT 518 560 WD 3.
 REPEAT 563 601 WD 4.
 REPEAT 604 643 WD 5.
 REPEAT 647 686 WD 6.
 REPEAT 702 732 WD 7.
 REGION 251 413 Sufficient for nucleolar localization.
 MOD_RES 112 112 Phosphoserine.
 MOD_RES 113 113 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 732 AA 
Protein Sequence
MAGACGKPHM SPASLPGKRR LEPDQELQIQ EPPLLSDPDS SLSDSEESVF SGLEDLGSDS 60
SEEDTEGVAG SSGDEDNHRA EETSEELAQA APLCSRTEEA GALAQDEYEE DSSDEEDIRN 120
TVGNVPLAWY DEFPHVGYDL DGKRIYKPLR TRDELDQFLD KMDDPDFWRT VQDKMTGRDL 180
RLTDEQVALV HRLQRGQFGD SGFNPYEPAV DFFSGDIMIH PVTNRPADKR SFIPSLVEKE 240
KVSRMVHAIK MGWIKPRRPH DPTPSFYDLW AQEDPNAVLG RHKMHVPAPK LALPGHAESY 300
NPPPEYLPTE EERSAWMQQE PVERKLNFLP QKFPSLRTVP AYSRFIQERF ERCLDLYLCP 360
RQRKMRVNVD PEDLIPKLPR PRDLQPFPVC QALVYRGHSD LVRCLSVSPG GQWLASGSDD 420
GTLKLWEVAT ARCMKTVHVG GVVRSIAWNP NPTICLVAAA MDDAVLLLNP ALGDRLLVGS 480
TDQLLEAFTP PEEPALQPAR WLEVSEEEHQ RGLRLRICHS KPVTQVTWHG RGDYLAVVLS 540
SQEHTQVLLH QVSRRRSQSP FRRSHGQVQC VAFHPSRPFL LVASQRSIRI YHLLRQELTK 600
KLMPNCKWVS SMAVHPAGDN IICGSYDSKL VWFDLDLSTK PYKVLRHHKK ALRAVAFHPR 660
YPLFASGSDD GSVIVCHGMV YNDLLQNPLL VPVKVLKGHT LTRDLGVLDV AFHPTQPWVF 720
SSGADGTIRL FS 732 
Gene Ontology
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0070545; C:PeBoW complex; ISS:UniProtKB.
 GO:0043021; F:ribonucleoprotein complex binding; IDA:MGI.
 GO:0008283; P:cell proliferation; IMP:UniProtKB.
 GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:UniProtKB.
 GO:0051726; P:regulation of cell cycle; ISS:UniProtKB. 
Interpro
 IPR012953; BOP1_N_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08145; BOP1NT
 PF00400; WD40 
SMART
 SM01035; BOP1NT
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS