UniProt Accession

 CRYAB_RAT; P23928; Q6LDR2 

Genbank Protein ID

 S74229; S77138; M55534; X60352; X60351; S77142; U04320; M24092 

Genbank Nucleotide ID

 AAB20759.1; AAP31995.1; AAA40977.1; CAA42911.1; CAA42910.1; AAA03655.1; AAA40978.1 

Protein Name

 Alpha-crystallin B chain 

Protein Synonyms/Alias

 Alpha(B)-crystallin 

Gene Name

 Cryab 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
82	FSVNLDVKHFSPEEL	acetylation	[1]
90	HFSPEELKVKVLGDV	acetylation	[1]
103	DVIEVHGKHEERQDE	acetylation	[1]
166	IPITREEKPAVTAAP	acetylation	[1]
174	PAVTAAPKK******	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. 

Sequence Annotation

 METAL 104 104 Zinc (By similarity).
 METAL 111 111 Zinc (By similarity).
 METAL 119 119 Zinc (By similarity).
 MOD_RES 1 1 N-acetylmethionine (Probable).
 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 22 22 Omega-N-methylated arginine (By
 MOD_RES 45 45 Phosphoserine (By similarity).
 MOD_RES 50 50 Omega-N-methylated arginine (By
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 92 92 N6-acetyllysine (By similarity).
 MOD_RES 166 166 N6-acetyllysine (By similarity).
 CARBOHYD 170 170 O-linked (GlcNAc).  

Keyword

 Acetylation; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Eye lens protein; Glycoprotein; Metal-binding; Methylation; Nucleus; Oxidation; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0032432; C:actin filament bundle; IDA:RGD.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0031674; C:I band; IDA:RGD.
 GO:0015630; C:microtubule cytoskeleton; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0005212; F:structural constituent of eye lens; TAS:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IMP:RGD.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0031109; P:microtubule polymerization or depolymerization; IMP:RGD.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0030308; P:negative regulation of cell growth; IDA:RGD.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0032387; P:negative regulation of intracellular transport; IEA:Compara.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IDA:RGD.
 GO:0006457; P:protein folding; IDA:RGD.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0051403; P:stress-activated MAPK cascade; IMP:RGD.
 GO:0007021; P:tubulin complex assembly; IEA:Compara. 

Interpro

 IPR002068; a-crystallin/Hsp20_dom.
 IPR001436; Alpha-crystallin/HSP.
 IPR012273; Alpha-crystallin_B.
 IPR003090; Alpha-crystallin_N.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF00525; Crystallin
 PF00011; HSP20 

SMART

  

PROSITE

 PS01031; HSP20 

PRINTS

 PR00299; ACRYSTALLIN.