UniProt Accession

 FADS2_MOUSE; Q9Z0R9 

Genbank Protein ID

 AF126798; AK143524; BC057189 

Genbank Nucleotide ID

 AAD20017.1; BAE25416.1; AAH57189.1 

Protein Name

 Fatty acid desaturase 2 

Protein Synonyms/Alias

 Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase 

Gene Name

 Fads2 

Gene Synonyms/Alias

 Fadsd2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	FRWEEIQKHNLRTDR	ubiquitination	[1]
48	RKVYNVTKWSQRHPG	ubiquitination	[1]
87	DFVGKFLKPLLIGEL	ubiquitination	[1]
105	EPSLDRGKSSQITED	ubiquitination	[1]
118	EDFRALKKTAEDMNL	ubiquitination	[1]
229	AKPNIFHKDPDIKSL	ubiquitination	[1]
398	MPRHNLHKIAPLVKS	ubiquitination	[1]
404	HKIAPLVKSLCAKHG	ubiquitination	[1]
409	LVKSLCAKHGIEYQE	ubiquitination	[1]
417	HGIEYQEKPLLRALI	ubiquitination	[1]
431	IDIVSSLKKSGELWL	ubiquitination	[1]
432	DIVSSLKKSGELWLD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity). 

Sequence Annotation

 DOMAIN 18 95 Cytochrome b5 heme-binding.
 MOTIF 180 184 Histidine box-1.
 MOTIF 217 221 Histidine box-2.
 MOTIF 382 386 Histidine box-3.  

Keyword

 Complete proteome; Electron transport; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 444 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; TAS:MGI.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; IDA:MGI.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR012171; Fatty_acid/sphinglp_desaturase.
 IPR005804; Fatty_acid_desaturase-1. 

Pfam

 PF00173; Cyt-b5
 PF00487; FA_desaturase 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 

PRINTS