UniProt Accession

 TECR_MOUSE; Q9CY27 

Genbank Protein ID

 AK010984; BC019984 

Genbank Nucleotide ID

 BAB27305.1; AAH19984.1 

Protein Name

 Very-long-chain enoyl-CoA reductase 

Protein Synonyms/Alias

 Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase; TER 

Gene Name

 Tecr 

Gene Synonyms/Alias

 Gpsn2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
2	******MKHYEVEIR	ubiquitination	[1]
16	RDAKTREKLCFLDKV	ubiquitination	[1]
22	EKLCFLDKVEPQATI	acetylation	[2]
22	EKLCFLDKVEPQATI	ubiquitination	[1]
38	EIKTLFTKTHPQWYP	ubiquitination	[1]
57	LRLDPKGKSLKDEDV	ubiquitination	[1]
60	DPKGKSLKDEDVLQK	acetylation	[2]
60	DPKGKSLKDEDVLQK	ubiquitination	[1]
67	KDEDVLQKLPVGTTA	ubiquitination	[1]
116	VPFIYGRKYDFTSSR	acetylation	[3]
291	GKHRSYLKEFRDYPP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (By similarity). 

Sequence Annotation

 MOD_RES 22 22 N6-acetyllysine (By similarity).
 MOD_RES 116 116 N6-acetyllysine.
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0030497; P:fatty acid elongation; ISS:UniProtKB.
 GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 

Pfam

 PF02544; Steroid_dh 

SMART

  

PROSITE

 PS50244; S5A_REDUCTASE 

PRINTS