CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SPRY domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 Spryd4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
53FRGDTGVKYGLVGLEacetylation[1, 2, 3]
95HYWEVTVKRSQQFRIacetylation[3]
139HSMLANEKAPIKGIGacetylation[3, 4]
139HSMLANEKAPIKGIGsuccinylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
 DOMAIN 12 207 B30.2/SPRY.
 MOD_RES 130 130 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MALPFARCWK LYRWGTKRWG VPAVESRRGI SFKLEEKTAH SSLALFRGDT GVKYGLVGLE 60
PTKVALNLER FREWAVVLGD TTVTSGRHYW EVTVKRSQQF RIGVADVDMS RDSCVGADDR 120
SWVFSYAQRK WHSMLANEKA PIKGIGQPEK VGLLLDYEAK KLSLVDVSRI SVIHTLQTDF 180
RGPVAPAFAL WDGELLTHSG LEVPKGL 207 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; ISS:UniProtKB. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
  
PROSITE
 PS50188; B302_SPRY 
PRINTS
 PR01407; BUTYPHLNCDUF.