UniProt Accession

 ANPRA_MOUSE; P18293 

Genbank Protein ID

 J05504; L31932 

Genbank Nucleotide ID

 AAA37670.1; AAA66945.1 

Protein Name

 Atrial natriuretic peptide receptor 1 

Protein Synonyms/Alias

 Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A 

Gene Name

 Npr1 

Gene Synonyms/Alias

 Npra 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
694	QGHTLFAKKLWTAPE	acetylation	[1]
694	QGHTLFAKKLWTAPE	ubiquitination	[2]
802	LALRKFNKENSSNIL	ubiquitination	[2]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. 

Sequence Annotation

 DOMAIN 524 801 Protein kinase.
 DOMAIN 872 1002 Guanylate cyclase.
 BINDING 81 81 Chloride (By similarity).
 BINDING 113 113 Chloride; via amide nitrogen (By
 BINDING 114 114 Chloride; via amide nitrogen (By
 MOD_RES 515 515 Phosphoserine (By similarity).
 MOD_RES 525 525 Phosphoserine (By similarity).
 MOD_RES 528 528 Phosphothreonine (By similarity).
 MOD_RES 530 530 Phosphoserine (By similarity).
 MOD_RES 534 534 Phosphoserine (By similarity).
 MOD_RES 538 538 Phosphoserine (By similarity).
 MOD_RES 541 541 Phosphothreonine (By similarity).
 CARBOHYD 41 41 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 CARBOHYD 334 334 N-linked (GlcNAc...) (Potential).
 CARBOHYD 375 375 N-linked (GlcNAc...) (Potential).
 CARBOHYD 382 382 N-linked (GlcNAc...) (Potential).
 CARBOHYD 423 423 N-linked (GlcNAc...) (Potential).
 DISULFID 88 114 By similarity.
 DISULFID 192 241 By similarity.
 DISULFID 451 460 By similarity.  

Keyword

 cGMP biosynthesis; Chloride; Complete proteome; Disulfide bond; Glycoprotein; GTP-binding; Lyase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Vasoactive. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1057 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004383; F:guanylate cyclase activity; IDA:MGI.
 GO:0016941; F:natriuretic peptide receptor activity; ISS:UniProtKB.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0042417; P:dopamine metabolic process; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0007168; P:receptor guanylyl cyclase signaling pathway; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW. 

Interpro

 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR001828; ANF_lig-bd_rcpt.
 IPR011009; Kinase-like_dom.
 IPR001170; Ntpep_rcpt.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom. 

Pfam

 PF01094; ANF_receptor
 PF00211; Guanylate_cyc
 PF07714; Pkinase_Tyr 

SMART

 SM00044; CYCc 

PROSITE

 PS00458; ANF_RECEPTORS
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2
 PS50011; PROTEIN_KINASE_DOM 

PRINTS

 PR00255; NATPEPTIDER.