CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000412
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurosecretory protein VGF 
Protein Synonyms/Alias
 Neuroendocrine regulatory peptide-1; NERP-1; Neuroendocrine regulatory peptide-2; NERP-2; Antimicrobial peptide VGF[554-577] 
Gene Name
 VGF 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246GPLPETHKFGEGVSSubiquitination[1]
255GEGVSSPKTHLGEALubiquitination[1]
267EALAPLSKAYQGVAAubiquitination[1]
278GVAAPFPKARRPESAubiquitination[1]
418GEAGAEDKRSQEETPubiquitination[1]
479IIEEVEEKRKRKKNAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system (By similarity). 
Sequence Annotation
 MOD_RES 310 310 Pyrrolidone carboxylic acid.
 MOD_RES 577 577 Proline amide.  
Keyword
 Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Growth factor; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG PKDGSAPEVR 60
GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS GSQQGPEEEA AEALLTETVR 120
SQTHSLPAPE SPEPAAPPRP QTPENGPEAS DPSEELEALA SLLQELRDFS PSSAKRQQET 180
AAAETETRTH TLTRVNLESP GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP 240
LPETHKFGEG VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG 300
LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG LQEAAEERES 360
AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ NALLFAEEED GEAGAEDKRS 420
QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ TIDSLIELST KLHLPADDVV SIIEEVEEKR 480
KRKKNAPPEP VPPPRAAPAP THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP 540
GPYHPFPNYI RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ 600
EELENYIEHV LLRRP 615 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
 GO:0006091; P:generation of precursor metabolites and energy; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0030073; P:insulin secretion; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0051591; P:response to cAMP; IEP:UniProtKB.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0002021; P:response to dietary excess; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0019953; P:sexual reproduction; IEA:Compara. 
Interpro
 IPR026128; VGF. 
Pfam
  
SMART
  
PROSITE
  
PRINTS