CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039779
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Stress-induced-phosphoprotein 1 
Protein Synonyms/Alias
  
Gene Name
 STIP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99EARLAERKFMNPFNMubiquitination[1, 2, 3, 4]
112NMPNLYQKLESDPRTubiquitination[3, 4]
145KPSDLGTKLQDPRIMacetylation[5]
145KPSDLGTKLQDPRIMubiquitination[2, 3, 4]
186PPPKKETKPEPMEEDacetylation[4, 5]
186PPPKKETKPEPMEEDubiquitination[4]
205KKQALKEKELGNDAYacetylation[4]
213ELGNDAYKKKDFDTAacetylation[4]
222KDFDTALKHYDKAKEacetylation[4, 5]
222KDFDTALKHYDKAKEubiquitination[3, 4]
248QAAVYFEKGDYNKCRubiquitination[6]
260KCRELCEKAIEVGREacetylation[4]
260KCRELCEKAIEVGREubiquitination[3, 4]
288RIGNSYFKEEKYKDAacetylation[4, 7]
293YFKEEKYKDAIHFYNacetylation[5]
293YFKEEKYKDAIHFYNubiquitination[3]
301DAIHFYNKSLAEHRTacetylation[4, 7]
301DAIHFYNKSLAEHRTubiquitination[1]
313HRTPDVLKKCQQAEKacetylation[4]
313HRTPDVLKKCQQAEKubiquitination[3, 4]
320KKCQQAEKILKEQERacetylation[4]
320KKCQQAEKILKEQERubiquitination[3, 4]
340PDLALEEKNKGNECFacetylation[4, 5]
349KGNECFQKGDYPQAMacetylation[4]
357GDYPQAMKHYTEAIKacetylation[8]
364KHYTEAIKRNPKDAKacetylation[4]
371KRNPKDAKLYSNRAAacetylation[4, 5]
405QLEPTFIKGYTRKAAacetylation[4, 5]
405QLEPTFIKGYTRKAAubiquitination[3, 4]
410FIKGYTRKAAALEAMubiquitination[3, 4]
418AAALEAMKDYTKAMDubiquitination[1]
422EAMKDYTKAMDVYQKacetylation[5]
422EAMKDYTKAMDVYQKubiquitination[1]
438LDLDSSCKEAADGYQacetylation[4]
438LDLDSSCKEAADGYQubiquitination[2, 3, 4, 9]
462HDSPEDVKRRAMADPubiquitination[2]
489LILEQMQKDPQALSEacetylation[5]
489LILEQMQKDPQALSEubiquitination[3, 4]
499QALSEHLKNPVIAQKubiquitination[4, 6]
506KNPVIAQKIQKLMDVacetylation[5, 7]
509VIAQKIQKLMDVGLIubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [8] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [9] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 519 AA 
Protein Sequence
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED 60
GCKTVDLKPD WGKGLKHEAN NPQLKEGLQN MEARLAERKF MNPFNMPNLY QKLESDPRTR 120
TLLSDPTYRE LIEQLRNKPS DLGTKLQDPR IMTTLSVLLG VDLGSMDEEE EIATPPPPPP 180
PKKETKPEPM EEDLPENKKQ ALKEKELGND AYKKKDFDTA LKHYDKAKEL DPTNMTYITN 240
QAAVYFEKGD YNKCRELCEK AIEVGRENRE DYRQIAKAYA RIGNSYFKEE KYKDAIHFYN 300
KSLAEHRTPD VLKKCQQAEK ILKEQERLAY INPDLALEEK NKGNECFQKG DYPQAMKHYT 360
EAIKRNPKDA KLYSNRAACY TKLLEFQLAL KDCEECIQLE PTFIKGYTRK AAALEAMKDY 420
TKAMDVYQKA LDLDSSCKEA ADGYQRCMMA QYNRHDSPED VKRRAMADPE VQQIMSDPAM 480
RLILEQMQKD PQALSEHLKN PVIAQKIQKL MDVGLIAIR 519 
Gene Ontology
  
Interpro
 IPR006636; STI1_HS-bd.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00727; STI1
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS