| Tag | Content |
|---|
| CPLM ID | CPLM-001391 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
Protein Synonyms/Alias | Brain cyclic nucleotide-gated channel 2; BCNG-2; Hyperpolarization-activated cation channel 1; HAC-1 |
Gene Name | Hcn2 |
Gene Synonyms/Alias | Bcng2; Hac1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | EGPARGPKVSFSCRG | ubiquitination | [1] | | 150 | LLQPGVNKFSLRMFG | ubiquitination | [1] | | 464 | EQYMSFHKLPADFRQ | ubiquitination | [1] | | 472 | LPADFRQKIHDYYEH | ubiquitination | [1] | | 510 | IVNFNCRKLVASMPL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. |
Sequence Annotation | NP_BIND 517 634 cAMP.
REGION 131 182 Involved in subunit assembly.
MOD_RES 119 119 Phosphoserine.
MOD_RES 641 641 Phosphoserine; by PKG/PRKG2.
MOD_RES 750 750 Phosphoserine.
MOD_RES 771 771 Phosphoserine.
CARBOHYD 380 380 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; cAMP; cAMP-binding; Complete proteome; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Nucleotide-binding; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 863 AA |
Protein Sequence | MDARGGGGRP GDSPGTTPAP GPPPPPPPPA PPQPQPPPAP PPNPTTPSHP ESADEPGPRA 60
RLCSRDSACT PGAAKGGANG ECGRGEPQCS PEGPARGPKV SFSCRGAASG PSAAEEAGSE 120
EAGPAGEPRG SQASFLQRQF GALLQPGVNK FSLRMFGSQK AVEREQERVK SAGAWIIHPY 180
SDFRFYWDFT MLLFMVGNLI IIPVGITFFK DETTAPWIVF NVVSDTFFLM DLVLNFRTGI 240
VIEDNTEIIL DPEKIKKKYL RTWFVVDFVS SIPVDYIFLI VEKGIDSEVY KTARALRIVR 300
FTKILSLLRL LRLSRLIRYI HQWEEIFHMT YDLASAVMRI CNLISMMLLL CHWDGCLQFL 360
VPMLQDFPSD CWVSINNMVN HSWSELYSFA LFKAMSHMLC IGYGRQAPES MTDIWLTMLS 420
MIVGATCYAM FIGHATALIQ SLDSSRRQYQ EKYKQVEQYM SFHKLPADFR QKIHDYYEHR 480
YQGKMFDEDS ILGELNGPLR EEIVNFNCRK LVASMPLFAN ADPNFVTAML TKLKFEVFQP 540
GDYIIREGTI GKKMYFIQHG VVSVLTKGNK EMKLSDGSYF GEICLLTRGR RTASVRADTY 600
CRLYSLSVDN FNEVLEEYPM MRRAFETVAI DRLDRIGKKN SILLHKVQHD LSSGVFNNQE 660
NAIIQEIVKY DREMVQQAEL GQRVGLFPPP PPPQVTSAIA TLQQAVAMSF CPQVARPLVG 720
PLALGSPRLV RRAPPGPLPP AASPGPPAAS PPAAPSSPRA PRTSPYGVPG SPATRVGPAL 780
PARRLSRASR PLSASQPSLP HGVPAPSPAA SARPASSSTP RLGPAPTART AAPSPDRRDS 840
ASPGAASGLD PLDSARSRLS SNL 863 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030552; F:cAMP binding; IEA:UniProtKB-KW. GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW. GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. GO:0042391; P:regulation of membrane potential; IDA:MGI. GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |