UniProt Accession

 CRBN_MOUSE; Q8C7D2; Q3TVC2; Q5RJV6; Q6IS49; Q80XJ1; Q8BP45; Q8C6B7; Q9JKR4 

Genbank Protein ID

 AK050557; AK076144; AK077707; AK160219; BC046967; BC069905; BC086488; AF229032 

Genbank Nucleotide ID

 BAC34322.1; BAC36214.1; BAC36970.1; BAE35697.1; AAH46967.1; AAH69905.1; AAH86488.1; AAF35895.1 

Protein Name

 Protein cereblon 

Protein Synonyms/Alias

 Protein PiL 

Gene Name

 Crbn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
303	VLRIQLLKIGSAIQR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). 

Sequence Annotation

 DOMAIN 83 320 Lon.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Membrane; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0031464; C:Cul4A-RING ubiquitin ligase complex; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
 GO:0034766; P:negative regulation of ion transmembrane transport; IEA:Compara.
 GO:0032463; P:negative regulation of protein homooligomerization; IEA:Compara.
 GO:0090073; P:positive regulation of protein homodimerization activity; IEA:Compara.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0016567; P:protein ubiquitination; ISS:UniProtKB. 

Interpro

 IPR003111; Pept_S16_N.
 IPR015947; PUA-like_domain. 

Pfam

 PF02190; LON 

SMART

 SM00464; LON 

PROSITE

  

PRINTS