| Tag | Content |
|---|
| CPLM ID | CPLM-000617 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ectoderm-neural cortex protein 1 |
Protein Synonyms/Alias | ENC-1 |
Gene Name | Enc1 |
Gene Synonyms/Alias | Enc-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 275 | EAIRCKLKILQNDGV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism (By similarity). |
Sequence Annotation | DOMAIN 46 114 BTB.
REPEAT 296 340 Kelch 1.
REPEAT 341 388 Kelch 2.
REPEAT 389 444 Kelch 3.
REPEAT 446 492 Kelch 4.
REPEAT 494 538 Kelch 5.
REPEAT 539 585 Kelch 6. |
Keyword | Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 589 AA |
Protein Sequence | MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH 60
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL 120
LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR 180
KNEDFLQLPQ DMVVQLLSSE ELETEDERLV YESAMNWISY DLKKRYCYLP ELLQTVRLAL 240
LPAIYLMENV AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL 300
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS ENGVSKDVWV 360
YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT GCLPASPSVS LKQVEQYDPT 420
TNKWTMVAPL REGVSNAAVV SAKLKLFAFG GTSVSHDKLP KVQCYDQCEN RWSVPATCPQ 480
PWRYTAAAVL GNQIFIMGGD TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL 540
YVVGGYFGIQ RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS 589 |
Gene Ontology | GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB. GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0017148; P:negative regulation of translation; ISS:UniProtKB. GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; ISS:UniProtKB. GO:0016567; P:protein ubiquitination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |