CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024269
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine-specific methyltransferase EgtD 
Protein Synonyms/Alias
 Histidine-alpha-N-methyltransferase 
Gene Name
 egtD 
Gene Synonyms/Alias
 MSMEG_6247; MSMEI_6086 
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
242DAFEHVAKWNSDEERpupylation[1]
Reference
 [1] Proteome-wide identification of mycobacterial pupylation targets.
 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH.
 Mol Syst Biol. 2010 Jul 13;6:386. [PMID: 20631680
Functional Description
 Catalyzes the methylations of histidine to form N- alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine). Histidine and alpha-N,N-dimethylhistidine are preferred substrates. 
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 321 AA 
Protein Sequence
MTLSLANYLA ADSAAEALRR DVRAGLTAAP KSLPPKWFYD AVGSDLFDQI TRLPEYYPTR 60
TEAQILRTRS AEIIAAAGAD TLVELGSGTS EKTRMLLDAM RDAELLRRFI PFDVDAGVLR 120
SAGAAIGAEY PGIEIDAVCG DFEEHLGKIP HVGRRLVVFL GSTIGNLTPA PRAEFLSTLA 180
DTLQPGDSLL LGTDLVKDTG RLVRAYDDAA GVTAAFNRNV LAVVNRELSA DFDLDAFEHV 240
AKWNSDEERI EMWLRARTAQ HVRVAALDLE VDFAAGEEML TEVSCKFRPE NVVAELAEAG 300
LRQTHWWTDP AGDFGLSLAV R 321 
Gene Ontology
 GO:0030745; F:dimethylhistidine N-methyltransferase activity; IEA:EC.
 GO:0008276; F:protein methyltransferase activity; IDA:UniProtKB.
 GO:0052704; P:ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine; IDA:UniProtKB.
 GO:0052707; P:N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine; IDA:UniProtKB. 
Interpro
 IPR019257; MeTrfase_DUF2260.
 IPR017804; MeTrfase_EgtD-like. 
Pfam
 PF10017; DUF2260 
SMART
  
PROSITE
  
PRINTS