UniProt Accession

 PEBP1_MOUSE; P70296; Q9D8G9; Q9JJ58 

Genbank Protein ID

 U43206; AF300422; AB046417; AK088212; BC008169; BC083063 

Genbank Nucleotide ID

 AAB06983.1; AAG25635.1; BAB03276.1; BAC40214.1; AAH08169.1; AAH83063.1 

Protein Name

 Phosphatidylethanolamine-binding protein 1 

Protein Synonyms/Alias

 PEBP-1; HCNPpp; Hippocampal cholinergic neurostimulating peptide; HCNP 

Gene Name

 Pebp1 

Gene Synonyms/Alias

 Pbp; Pebp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	DPDAPSRKDPKFREW	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). 

Sequence Annotation

 REGION 93 134 Interaction with RAF1 (By similarity).
 MOD_RES 2 2 N-acetylalanine; in peptide hippocampal
 MOD_RES 42 42 Phosphothreonine (By similarity).
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 54 54 Phosphoserine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Lipid-binding; Nucleotide-binding; Phosphoprotein; Protease inhibitor; Reference proteome; Serine protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0009986; C:cell surface; IDA:MGI.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042755; P:eating behavior; IEA:Compara.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0043409; P:negative regulation of MAPK cascade; IEA:Compara.
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0060409; P:positive regulation of acetylcholine metabolic process; IEA:Compara.
 GO:0043950; P:positive regulation of cAMP-mediated signaling; IEA:Compara.
 GO:0045840; P:positive regulation of mitosis; IEA:Compara.
 GO:0001505; P:regulation of neurotransmitter levels; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0048240; P:sperm capacitation; IDA:MGI. 

Interpro

 IPR001858; Phosphotidylethanolamine-bd_CS.
 IPR008914; PtdEtn-bd_prot_PEBP. 

Pfam

 PF01161; PBP 

SMART

  

PROSITE

 PS01220; PBP 

PRINTS