| Tag | Content |
|---|
| CPLM ID | CPLM-023347 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cleavage and polyadenylation specificity factor subunit 1 |
Protein Synonyms/Alias | Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit; dCPSF 160 |
Gene Name | Cpsf160 |
Gene Synonyms/Alias | cpsf; CG10110 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 181 | EIELADVKPIKKAPT | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; mRNA processing; Nucleus; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1455 AA |
Protein Sequence | MFSMCKQTHS ATAVEFSIAC RFFNNLDENL VVAGANVLKV YRIAPNVEAS QRQKLNPSEM 60
RLAPKMRLEC LATYTLYGNV MSLQCVSLAG AMRDALLISF KDAKLSVLQH DPDTFALKTL 120
SLHYFEEDDI RGGWTGRYFV PTVRVDPDSR CAVMLVYGKR LVVLPFRKDN SLDEIELADV 180
KPIKKAPTAM VSRTPIMASY LIALRDLDEK IDNVLDIQFL HGYYEPTLLI LYEPVRTCPG 240
RIKVRSDTCV LVAISLNIQQ RVHPIIWTVN SLPFDCLQVY PIQKPIGGCL VMTVNAVIYL 300
NQSVPPYGVS LNSSADNSTA FPLKPQDGVR ISLDCANFAF IDVDKLVISL RTGDLYVLTL 360
CVDSMRTVRN FHFHKAAASV LTSCICVLHS EYIFLGSRLG NSLLLHFTEE DQSTVITLDE 420
VEQQSEQQQR NLQDEDQNLE EIFDVDQLEM APTQAKSRRI EDEELEVYGS GAKASVLQLR 480
KFIFEVCDSL MNVAPINYMC AGERVEFEED GVTLRPHAES LQDLKIELVA ATGHSKNGAL 540
SVFVNCINPQ IITSFELDGC LDVWTVFDDA TKKSSRNDQH DFMLLSQRNS TLVLQTGQEI 600
NEIENTGFTV NQPTIFVGNL GQQRFIVQVT TRHVRLLQGT RLIQNVPIDV GSPVVQVSIA 660
DPYVCLRVLN GQVITLALRE TRGTPRLAIN KHTISSSPAV VAISAYKDLS GLFTVKGDDI 720
NLTGSSNSAF GHSFGGYMKA EPNMKVEDEE DLLYGDAGSA FKMNSMADLA KQSKQKNSDW 780
WRRLLVQAKP SYWLVVARQS GTLEIYSMPD MKLVYLVNDV GNGSMVLTDA MEFVPISLTT 840
QENSKAGIVQ ACMPQHANSP LPLELSVIGL GLNGERPLLL VRTRVELLIY QVFRYPKGHL 900
KIRFRKMDQL NLLDQQPTHI DLDENDEQEE IESYQMQPKY VQKLRPFANV GGLSGVMVCG 960
VNPCFVFLTF RGELRIHRLL GNGDVRSFAA FNNVNIPNGF LYFDTTYELK ISVLPSYLSY 1020
DSVWPVRKVP LRCTPRQLVY HRENRVYCLI TQTEEPMTKY YRFNGEDKEL SEESRGERFI 1080
YPIGSQFEMV LISPETWEIV PDASITFEPW EHVTAFKIVK LSYEGTRSGL KEYLCIGTNF 1140
NYSEDITSRG NIHIYDIIEV VPEPGKPMTK FKIKEIFKKE QKGPVSAISD VLGFLVTGLG 1200
QKIYIWQLRD GDLIGVAFID TNIYVHQIIT VKSLIFIADV YKSISLLRFQ EEYRTLSLAS 1260
RDFNPLEVYG IEFMVDNSNL GFLVTDAERN IIVYMYQPEA RESLGGQKLL RKADYHLGQV 1320
VNTMFRVQCH QKGLHQRQPF LYENKHFVVY GTLDGALGYC LPLPEKVYRR FLMLQNVLLS 1380
YQEHLCGLNP KEYRTLKSSK KQGINPSRCI IDGDLIWSYR LMANSERNEV AKKIGTRTEE 1440
ILGDLLEIER LASVF 1455 |
Gene Ontology | GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; ISS:FlyBase. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006379; P:mRNA cleavage; ISS:FlyBase. GO:0006378; P:mRNA polyadenylation; ISS:FlyBase. GO:0022008; P:neurogenesis; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |