UniProt Accession

 HMOX1_RAT; P06762; Q5BK87 

Genbank Protein ID

 J02722; BC091164 

Genbank Nucleotide ID

 AAA41346.1; AAH91164.1 

Protein Name

 Heme oxygenase 1 

Protein Synonyms/Alias

 HO-1; HSP32 

Gene Name

 Hmox1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
149	SGGQVLKKIAQKAMA	acetylation	[1]
153	VLKKIAQKAMALPSS	acetylation	[1]

Reference

 [1] Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase.
 Higashimoto Y, Sugishima M, Sato H, Sakamoto H, Fukuyama K, Palmer G, Noguchi M.
 Biochem Biophys Res Commun. 2008 Mar 21;367(4):852-8. [PMID: 18194664] 

Functional Description

 Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. 

Sequence Annotation

 METAL 25 25 Iron (heme axial ligand).
 BINDING 18 18 Heme (By similarity).
 BINDING 134 134 Heme (By similarity).
 BINDING 183 183 Heme (By similarity).
 MOD_RES 229 229 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:RGD.
 GO:0020037; F:heme binding; IDA:RGD.
 GO:0004392; F:heme oxygenase (decyclizing) activity; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004630; F:phospholipase D activity; IDA:RGD.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IDA:RGD.
 GO:0071276; P:cellular response to cadmium ion; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0031670; P:cellular response to nutrient; IEP:RGD.
 GO:0034101; P:erythrocyte homeostasis; IEA:Compara.
 GO:0042167; P:heme catabolic process; IDA:RGD.
 GO:0006788; P:heme oxidation; TAS:RGD.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:RGD.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IDA:RGD.
 GO:0032764; P:negative regulation of mast cell cytokine production; IDA:RGD.
 GO:0043305; P:negative regulation of mast cell degranulation; IDA:RGD.
 GO:0010656; P:negative regulation of muscle cell apoptotic process; IDA:RGD.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:RGD.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0006644; P:phospholipid metabolic process; TAS:RGD.
 GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IDA:RGD.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IDA:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IDA:RGD.
 GO:0042542; P:response to hydrogen peroxide; IDA:BHF-UCL.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0035094; P:response to nicotine; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
 GO:0002246; P:wound healing involved in inflammatory response; IEA:Compara. 

Interpro

 IPR002051; Haem_Oase.
 IPR016053; Haem_Oase-like.
 IPR016084; Haem_Oase-like_multi-hlx.
 IPR018207; Haem_oxygenase_CS. 

Pfam

 PF01126; Heme_oxygenase 

SMART

  

PROSITE

 PS00593; HEME_OXYGENASE 

PRINTS

 PR00088; HAEMOXYGNASE.