CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027526
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tau-tubulin kinase 
Protein Synonyms/Alias
  
Gene Name
 TTBK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
369RFLEQQNKMLETKWSubiquitination[1]
537QRGELAIKDANAKLSubiquitination[1]
1390LVKLLVEKRQFKSFLubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Intermediate filament; Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1649 AA 
Protein Sequence
MESVEKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCCFEK AARKDHVCRF 60
IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR LGRQILESIE SIHSVGFLHR 120
DIKPSNFAMG RFPSTCRKCY MLDFGLARQF TNSCGDVRPP RAVAGFRGTV RYASINAHRN 180
REMGRHDDLW SLFYMLVEFV VGQLPWRKIK DKEQVGSIKE RYDHRLMLKH LPPEFSIFLD 240
HISSLDYFTK PDYQMSIRVT RKSYKVSTSG PQAFNSLSYT SGPGACISSS SFSRMGSSSF 300
RGGLGAGYGG ASGGITTITV NQSLLSPLNL EVDPNIQAVR TQEEKQIKTL NNKFFSFIDK 360
VRFLEQQNKM LETKWSLVQQ QKMARSNMDN MFESYINNLK WQLETLGQEK LKLEAELGNM 420
HGLVEDFRNK YEVEISKCTE MENEFVLIKE YVDEAYMNKM ELESSLKELT AKISFLRQLY 480
EEEIGSCSPR SRIHLWCCSW TTAASWTWTA SSLRSRPEGF PGGCHADTEQ RGELAIKDAN 540
AKLSELEAAL QLASQDMARQ LREYQELMNV KLALDIKIAT YRKLLEGEES WLESGMQNMS 600
IHMKTTSSYA GGQSLAYGGL TSPGLSYGLG SSFGSGMGSS SFSHTSSSRA VVMKKIETRD 660
GKLVSESSNV LPNLRITATL LTSVFDNSIK TFGVIESDPF DWEKTGNDGS LTTTTTSTTP 720
QLHTRLTPAA IGIANATPIP GDLLRENTDE VFPDEQLSDG ENGIPVGVSP DKLPGSLGHP 780
RPQEKDVWEE MDANKNKIKL GICKAATEEE NSHGQANGLL NAPSLGSPIR VRSEITQPDR 840
DIPLVRKLRS IHSFELEKRL TLEPKPDTDK FLETCLEKMQ KDTSAGKESI LPALLHKPCV 900
PAVSRTDHIW HYDEEYLPDA SKPASANTPE QADGGGSNGF IAVNLSSCKQ EIDSKEWVIV 960
DKEQDLQDFR TNEAVGHKTT GSPSDEEPEV LQVLEASPQD EKLQLGPWAE NDHLKKETSG 1020
VVLALSAEGP PTAASEQYTD RLELQPGAAS QFIAATPTSL MEAQAEGPLT AITIPRPSVA 1080
STQSTSGSFH CGQQPEKKDL QPMEPTVELY SPRENFSGLV VTEGEPPSGG SRTDLGLQID 1140
HIGHDMLPNI RESNKSQDLG PKELPDHNRL VVREFENLPG ETEEKSILLE SDNEDEKLSR 1200
GQHCIEISSL PGDLVIVEKD HSATTEPLDV TKTQTFSVVP NQDKNNEIMK LLTVGTSEIS 1260
SRDIDPHVEG QIGQVAEMQK NKISKDDDIM SEDLPGHQGD LSTFLHQEGK REKITPRNGE 1320
LFHCVSENEH GAPTRKDMVR SSFVTRHSRI PVLAQEIDST LESSSPVSAK EKLLQKKAYQ 1380
PDLVKLLVEK RQFKSFLGDL SSASDKLLEE KLATVPAPFC EEEVLTPFSR LTVDSHLSRS 1440
AEDSFLSPII SQSRKSKIPR PVSWVNTDQV NSSTSSQFFP RPPPGKPPTR PGVEARLRRY 1500
KVLGSSNSDS DLFSRLAQIL QNGSQKPRST TQCKSPGSPH NPKTPPKSPV VPRRSPSASP 1560
RSSSLPRTSS SSPSRAGRPH HDQRSSSPHL GRSKSPPSHS GSSSSRRSCQ QEHCKPSKNG 1620
LKGSGSLHHH SASTKTPQGK SKPASKLSR 1649 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 
Pfam
 PF00038; Filament
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00226; IF
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR01276; TYPE2KERATIN.