UniProt Accession

 NOP3_YEAST; Q01560; D6VT60 

Genbank Protein ID

 X66019; M86731; X70951; U33007; BK006938 

Genbank Nucleotide ID

 CAA46817.1; AAA34818.1; CAA50291.1; AAB64865.1; DAA12270.1 

Protein Name

 Nucleolar protein 3 

Protein Synonyms/Alias

 Mitochondrial targeting suppressor 1 protein; Nuclear polyadenylated RNA-binding protein 1 

Gene Name

 NPL3 

Gene Synonyms/Alias

 MTR13; MTS1; NAB1; NOP3; YDR432W; D9461.19 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
181	AIEEVHGKSFANQPL	acetylation	[1]
194	PLEVVYSKLPAKRYR	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Required for pre-rRNA processing and nuclear import as well as mitochondrial protein targeting. Binds to poly(A). 

Sequence Annotation

 DOMAIN 125 195 RRM 1.
 DOMAIN 200 275 RRM 2.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 224 224 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IMP:SGD.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0031370; F:eukaryotic initiation factor 4G binding; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008143; F:poly(A) RNA binding; IDA:SGD.
 GO:0006406; P:mRNA export from nucleus; IGI:SGD.
 GO:0000398; P:mRNA splicing, via spliceosome; IMP:SGD.
 GO:2000805; P:negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled; IMP:SGD.
 GO:0017148; P:negative regulation of translation; IDA:SGD.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0006415; P:translational termination; IMP:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS