CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023461
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA polymerase-associated protein Rtf1 
Protein Synonyms/Alias
 dRtf1 
Gene Name
 Rtf1 
Gene Synonyms/Alias
 CG10955 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
180RLNGLSEKERETEIYacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat-shock genes. Plays a role in Notch signaling in the wing margins. 
Sequence Annotation
 DOMAIN 428 559 Plus3.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 53 53 Phosphoserine.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 271 271 Phosphoserine.
 MOD_RES 384 384 Phosphotyrosine.
 MOD_RES 385 385 Phosphoserine.
 MOD_RES 388 388 Phosphoserine.
 MOD_RES 390 390 Phosphoserine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 412 412 Phosphoserine.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 415 415 Phosphoserine.  
Keyword
 Activator; Chromosome; Coiled coil; Complete proteome; Notch signaling pathway; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 775 AA 
Protein Sequence
MGKRRTQSLI DSNSSDSDSE SETNLESDLM SLAKKRKKPQ TAAKSSSRSD SDSDWANNKA 60
GAPSSKKKKR QKPSRDSSSS ESNWDDDSQD ERQPARQSPA QTQQEHKPPE QASQPAQLSE 120
QEEGEVSDSD SDKSKSNSSS SGSDSSSSSS SSDSEFDDGF DDDLMGDDED RRRLNGLSEK 180
ERETEIYKRI EQREIMRTRW EIERKLKLAR RGEKNQEKSK NKGERAKKKK EKREKKARKA 240
REAQAPLPTQ ASTSTLLDVE PKPSNEVRSA SPLSTPALNR DAASTSAAVA SIMPDDAASS 300
AGVSDYFDHK ERSKERKKNV EANKTDDKRS NAMALLKAKR EGKAKREEEE AKRMAEKDRD 360
DDKEELDSVS GCKSAVKLKA SEIYSDDSGS SDWDEEEKPA GKRSRSNSSK ASSESEDEEK 420
APQRPVFITT REDLNKLRLS RYKMERFVNL PIFESTVLNC FVRISIGNNG QKPVYRVAEI 480
VGVVETGKIY SLGTTRTNRG LRLKHGTQER VFRLEFISNQ EFTENEFNKW NEVCQQSHVQ 540
MPTIDLIAIK QNDIKKALNY EFKDEDVDKI VEEKNRFRNR PTNYAMKKTC LMKERDAAML 600
RGDYDIAQDL GQQIDELENR ASELDKRRSH TLNLISYIND RNRKKNVEDA EKAILEEARA 660
NKGLKISDPF TRRITQPRMG FKGAKKDEDD MQLAPLPPPP PGKKRPNEAG TSSASVRSTD 720
SKDYSLYSLH DFDIDLDVPL PVNTNSVPKP ASKPAETVSK RSLNLEDYKK KRGLI 775 
Gene Ontology
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0035327; C:transcriptionally active chromatin; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IMP:UniProtKB.
 GO:0006352; P:DNA-dependent transcription, initiation; IEA:InterPro.
 GO:0007219; P:Notch signaling pathway; IMP:UniProtKB.
 GO:0051571; P:positive regulation of histone H3-K4 methylation; IMP:FlyBase.
 GO:0045747; P:positive regulation of Notch signaling pathway; IGI:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:FlyBase. 
Interpro
 IPR004343; Plus-3.
 IPR018144; Plus3-dom_subgr. 
Pfam
 PF03126; Plus-3 
SMART
 SM00719; Plus3 
PROSITE
 PS51360; PLUS3 
PRINTS