CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RING finger protein 145 
Protein Synonyms/Alias
  
Gene Name
 RNF145 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
523LRAQLGWKSFLLRRDubiquitination[1, 2, 3, 4, 5, 6]
536RDAVNKIKSLPIATKubiquitination[2, 4, 5, 6]
543KSLPIATKEQLEKHNubiquitination[2, 4, 5, 6]
548ATKEQLEKHNDICAIubiquitination[4, 6]
561AICYQDMKSAVITPCubiquitination[3, 4]
579FHAGCLKKWLYVQETubiquitination[4, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 679 AA 
Protein Sequence
MAEVFSKKKK KKKKNNMAAK EKLEAVLNVA LRVPSIMLLD VLYRWDVSSF FQQIQRSSLS 60
NNPLFQYKYL ALNMHYVGYI LSVVLLTLPR QHLVQLYLYF LTALLLYAGH QISRDYVRSE 120
LEFAYEGPMY LEPLSMNRFT TALIGQLVVC TLCSCVMKTK QIWLFSAHML PLLARLCLVP 180
LETIVIINKF AMIFTGLEVL YFLGSNLLVP YNLAKSAYRE LVQVVEVYGL LALGMSLWNQ 240
LVVPVLFMVF WLVLFALQIY SYFSTRDQPA SRERLLFLFL TSIAECCSTP YSLLGLVFTV 300
SFVALGVLTL CKFYLQGYRA FMNDPAMNRG MTEGVTLLIL AVQTGLIELQ VVHRAFLLSI 360
ILFIVVASIL QSMLEIADPI VLALGASRDK SLWKHFRAVS LCLFLLVFPA YMAYMICQFF 420
HMDFWLLIII SSSILTSLQV LGTLFIYVLF MVEEFRKEPV ENMDDVIYYV NGTYRLLEFL 480
VALCVVAYGV SETIFGEWTV MGSMIIFIHS YYNVWLRAQL GWKSFLLRRD AVNKIKSLPI 540
ATKEQLEKHN DICAICYQDM KSAVITPCSH FFHAGCLKKW LYVQETCPLC HCHLKNSSQL 600
PGLGTEPVLQ PHAGAEQNVM FQEGTEPPGQ EHTPGTRIQE GSRDNNEYIA RRPDNQEGAF 660
DPKEYPHSAK DEAHPVESA 679 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR025754; TRC8_N_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13705; TRC8_N
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2 
PRINTS