| Tag | Content |
|---|
| CPLM ID | CPLM-000199 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingolipid delta(4)-desaturase DES1 |
Protein Synonyms/Alias | Degenerative spermatocyte homolog 1 |
Gene Name | Degs1 |
Gene Synonyms/Alias | Degs; Des1; Mdes |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | KNLPMVRKIASEYYD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). |
Sequence Annotation | MOD_RES 307 307 Phosphoserine (By similarity).
LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lipoprotein; Membrane; Mitochondrion; Myristate; Oxidoreductase; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 323 AA |
Protein Sequence | MGSRVSREEF EWVYTDQPHA ARRKEILAKY PEIKSLMKPD HNLIWIVAMM LLVQLASFYL 60
VKDLDWKWVI FWSYVFGSCL NHSMTLAIHE ISHNFPFGHH KALWNRWFGM FANLSLGVPY 120
SISFKRYHMD HHRYLGADKI DVDIPTDFEG WFFCTTFRKF VWVILQPLFY AFRPLFINPK 180
PITYLEIINT VIQITFDIII YYVFGVKSLV YMLAATLLGL GLHPISGHFI AEHYMFLKGH 240
ETYSYYGPLN LLTFNVGYHN EHHDFPNVPG KNLPMVRKIA SEYYDDLPHY NSWIKVLYDF 300
VTDDTISPYS RMKRPPKGNE ILE 323 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |