UniProt Accession

 HEK2_YEAST; P38199; D6VPW7; E9P8X5 

Genbank Protein ID

 X77291; Z35793; AY692814; BK006936 

Genbank Nucleotide ID

 CAA54496.1; CAA84852.1; AAT92833.1; DAA07087.1 

Protein Name

 Heterogeneous nuclear rnp K-like protein 2 

Protein Synonyms/Alias

 KH domain-containing protein 1 

Gene Name

 HEK2 

Gene Synonyms/Alias

 KHD1; YBL032W; YBL0418 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
82	VKIGISEKVPGCSDR	acetylation	[1]
314	RKFIITSKFPKNVKL	acetylation	[1]
343	KRENYKRKLEAAEGD	ubiquitination	[2, 3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Required for the asymmetric localization to the daughter cell nucleus of the ASH1 transcript, coding for a specific repressor of transcription. Overexpression inhibits translation of the ASH1 transcript. Involved in the stability of transcripts such as the MTL1 mRNA. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus. 

Sequence Annotation

 DOMAIN 43 107 KH 1.
 DOMAIN 156 221 KH 2.
 DOMAIN 258 326 KH 3.
 MOD_RES 360 360 Phosphoserine.
 MOD_RES 362 362 Phosphoserine.  

Keyword

 Chromatin regulator; Chromosome; Complete proteome; Cytoplasm; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Telomere; Translation regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:SGD.
 GO:0003729; F:mRNA binding; IDA:SGD.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0008298; P:intracellular mRNA localization; IMP:SGD.
 GO:0048255; P:mRNA stabilization; IMP:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0007004; P:telomere maintenance via telomerase; IPI:SGD. 

Interpro

 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 

Pfam

 PF00013; KH_1
 PF13014; KH_3 

SMART

 SM00322; KH 

PROSITE

 PS50084; KH_TYPE_1 

PRINTS