CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disks large homolog 1 
Protein Synonyms/Alias
  
Gene Name
 Dlg1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
593RALFDYDKTKDSGLPacetylation[1]
593RALFDYDKTKDSGLPubiquitination[2]
643EVGVIPSKRRVEKKEubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 911 AA 
Protein Sequence
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVISI FQSNLFQALI DIQEFYEVTL 60
LDNPKCVDHS KQCEPVQPGN PWESGSLSSA AVTSESLPGG LSPPVEKYRY QDEEVLPSER 120
ISPQVPNEVL GPELVHVSEK SLSEIENVHG FVSHSHISPI KPTEAVPPSS PIVPVTPALP 180
VPAESPVVLP STPQANPPPV LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG 240
GTDNPHIGDD SSIFITKIIT GGAAAQDGRL RVNDCILRVN EADVRDVTHS KAVEALKEAG 300
SIVRLYVKRR KSLRKNHEIK LIKGPKGLGF SIAGGVGNQH IPGDNSIYVT KIIEGGAAHK 360
DGKLQIGDKL LAVNSVCLEE VTHEEAVTAL KNTSDFVYLK VAKPTSMYIN DGYAPPDITN 420
SSSQSVDNHV SPSSYLGQTP ASPARYSPIS KAVLGDDEIT REPRKVVLHR GSTGLGFNIV 480
GGEDGEGIFI SFILAGGPAD LSGELRKGDR IISVNSVDLR AASHEQAAAA LKNAGQAVTI 540
VAQYRPEEYS RFEAKIHDLR EQMMNSSVSS GSGSLRTSQK RSLYVRALFD YDKTKDSGLP 600
SQGLNFKFGD ILHVINASDD EWWQARQVTP DGESDEVGVI PSKRRVEKKE RARLKTVKFN 660
SKTRGDKGEI PDDMGSKGLK HVTSNASDSE SSYHEYGCSK GGQEEYVLSY EPVNQQEVNY 720
TRPVIILGPM KDRVNDDLIS EFPDKFGSCV PHTTRPKRDY EVDGRDYHFV TSREQMEKDI 780
QEHKFIEAGQ YNNHLYGTSV QSVRAVAEKG KHCILDVSGN AIKRLQIAQL YPISIFIKPK 840
SMENIMEMNK RLTDEQARKT FERAVRLEQE FTEHFTAIVQ GDTLEDIYNQ VKQIIEEQSG 900
PYIWVPAKEK L 911 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031253; C:cell projection membrane; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0043219; C:lateral loop; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0033268; C:node of Ranvier; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0032147; P:activation of protein kinase activity; IEA:Compara.
 GO:0042982; P:amyloid precursor protein metabolic process; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:Compara.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0060022; P:hard palate development; IEA:Compara.
 GO:0001771; P:immunological synapse formation; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0031579; P:membrane raft organization; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0030432; P:peristalsis; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0048608; P:reproductive structure development; IEA:Compara.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara.
 GO:0042110; P:T cell activation; IEA:Compara.
 GO:0002369; P:T cell cytokine production; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR004172; L27.
 IPR015143; L27_1.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF09058; L27_1
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50002; SH3 
PRINTS