UniProt Accession

 PCY1B_HUMAN; Q9Y5K3; A8IX00; B2RCX8; B4DK10; E9PD84; O60621; Q86XC9 

Genbank Protein ID

 AF052510; AF148464; AK296333; AK315323; EU181262; AC079168; CH471074; BC045634 

Genbank Nucleotide ID

 AAC39754.1; AAD35088.1; BAG59022.1; BAG37725.1; ABW03924.1; EAW99021.1; AAH45634.2 

Protein Name

 Choline-phosphate cytidylyltransferase B 

Protein Synonyms/Alias

 CCT-beta; CTP:phosphocholine cytidylyltransferase B; CCT B; CT B; Phosphorylcholine transferase B 

Gene Name

 PCYT1B 

Gene Synonyms/Alias

 CCTB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
183	AGSDDVYKHIKEAGM	ubiquitination	[1]
228	LQRGYTAKELNVSFI	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Controls phosphatidylcholine synthesis. 

Sequence Annotation

 NP_BIND 84 92 CTP (By similarity).
 NP_BIND 168 169 CTP (By similarity).
 NP_BIND 196 200 CTP (By similarity).
 BINDING 122 122 CTP (By similarity).
 BINDING 122 122 Substrate (By similarity).
 BINDING 151 151 Substrate (By similarity).
 BINDING 173 173 CTP (By similarity).
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 319 319 Phosphoserine.
 MOD_RES 325 325 Phosphothreonine (By similarity).
 MOD_RES 362 362 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0004105; F:choline-phosphate cytidylyltransferase activity; TAS:ProtInc.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS