CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Golgi-associated PDZ and coiled-coil motif-containing protein 
Protein Synonyms/Alias
 PDZ protein interacting specifically with TC10; PIST 
Gene Name
 Gopc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
94TVSQINHKLEAQLVDubiquitination[1]
351NLRDTKHKEAVTILSubiquitination[1]
410GNSGASCKDSSGEMKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. 
Sequence Annotation
 DOMAIN 289 372 PDZ.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MSAGGPCPAG AGGGPGGSSC PVGVSPGGVS MFRWLEVLEK EFDKAFVDVD LLLGEIDPDQ 60
ADITYEGRQK MTSLSSCFAQ LCHKAQTVSQ INHKLEAQLV DLRSELTETQ AEKVVLEKEV 120
HEQLLQLHST QLQLHAKTGQ SVDSGAIKAK LSVHSVEDLE RELEANKTEK VKEARLEAEV 180
KLLRKENEAL RRHIAVLQAE VYGARLAAKY LDKELAGRVQ QIQLLGRDMK GPAHDKLWNQ 240
LEAEIHLHRH KTVIRACRGR NDLKRPMQAP PGHDQDSLKK SQGVGPIRKV LLLKEDHEGL 300
GISITGGKEH GVPILISEIH PGQPADRCGG LHVGDAILAV NGVNLRDTKH KEAVTILSQQ 360
RGEIEFEVVY VAPEVDSDDE NVEYEDESGH RYRLYLDELE GSGNSGASCK DSSGEMKMLQ 420
GYNKKAVRDA HENGDVGAAG ESPLDDTAAR AAHLHSLHQK KAY 463 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0043234; C:protein complex; ISO:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
 GO:0044325; F:ion channel binding; ISS:UniProtKB.
 GO:0005083; F:small GTPase regulator activity; IDA:MGI.
 GO:0019905; F:syntaxin binding; ISS:UniProtKB.
 GO:0006914; P:autophagy; TAS:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007289; P:spermatid nucleus differentiation; IMP:MGI. 
Interpro
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS