CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030579
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ39640 fis, clone SMINT2003386, highly similar to DNA REPLICATION LICENSING FACTOR MCM7 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
450QFEPLDMKLMRRYIAubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; DNA replication; DNA-binding; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 612 AA 
Protein Sequence
MMEQRSRDPG MVRSPQNQYP AELMRRFELY FQGPSSSKPR VIREVRADSV GKLVTVRGIV 60
TRVSEVKPKM VVATYTCDQC GAETYQPIQS PTFMPLIMCP SQECQTNRSG GRLYLQTRGS 120
RFIKFQEMKM QEHSDQVPVG NIPRSITVLV EGENTRIAQP GDHVSVTGIF LPILRTGFRQ 180
VVQGLLSETY LEAHRIVKMN KSEDDESGAG ELTREELRQI AEEDFYEKLA ASIAPEIYGH 240
EDVKKALLLL LVGGVDQSPR GMKIRGNINI CLMGDPGVAK SQLLSYIDRL APRSQYTTGR 300
GSSGVGLTAA VLRDSVSGEL TLEGGALVLA DQGVCCIDEF DKMAEADRTA IHEVMEQQTI 360
SIAKAGILTT LNARCSILAA ANPAYGRYNP RRSLEQNIQL PAALLSRFDL LWLIQDRPDR 420
DNDLRLAQHI TYVHQHSRQP PSQFEPLDMK LMRRYIAMCR EKQPMVPESL ADYITAAYVE 480
MRREAWASKD ATYTSARTLL AILRLSTALA RLRMVDVVEK EDVNEAIRLM EMSKDSLLGD 540
KGQTARTQRP ADVIFATVRE LVSGGRSVRF SEAEQRCVSR GFTPAQFQAA LDEYEELNVW 600
QVNASRTRIT FV 612 
Gene Ontology
 GO:0042555; C:MCM complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003678; F:DNA helicase activity; IEA:InterPro.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006270; P:DNA replication initiation; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR008050; MCM7.
 IPR018525; MCM_CS.
 IPR001208; MCM_DNA-dep_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00493; MCM 
SMART
 SM00382; AAA
 SM00350; MCM 
PROSITE
 PS00847; MCM_1
 PS50051; MCM_2 
PRINTS
 PR01657; MCMFAMILY.
 PR01663; MCMPROTEIN7.