CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative phosphatidylinositol 4-kinase alpha-like protein P2 
Protein Synonyms/Alias
  
Gene Name
 PI4KAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
216TNVSAIIKPYPKGDEubiquitination[1, 2, 3, 4]
267TPMQSAAKAPYLAKFubiquitination[4, 5]
273AKAPYLAKFKVKRCGubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 DOMAIN 312 592 PI3K/PI4K.
 REGION 180 318 Pleckstrin homology (PH) domain  
Keyword
 Alternative splicing; Complete proteome; Kinase; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 592 AA 
Protein Sequence
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV 60
EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK 120
IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLLE 180
QLVEENTGSL SGPAKDFYQR EFDFFNKITN VSAIIKPYPK GDERKKACLS ALSEVTVQPG 240
CSLPSNPEAI VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS 300
TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RTPTDRILRL PASQDMLALQ IIDLFKNIFQ 360
LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD FGMYDYFTRQ YGDESTLAFQ 420
QACYNFIRSM AAYSLLLFLL QIKDRHNGNI MLDKKGHIIH IDFGFMFESS PGGNLGWEPD 480
IKLTDEMVMI MGGKMEATPF KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR 540
GQTIKFLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY 592 
Gene Ontology
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR015433; PI_Kinase. 
Pfam
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS