UniProt Accession

 CMGA_HUMAN; P10645; B2R9E9; Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5 

Genbank Protein ID

 J03483; J03915; U03749; U03742; U03743; U03744; U03748; U03745; U03746; U03747; BT006869; AK223381; AL117192; AK313757; CH471061; BC001059; BC006459; BC009384; BC012755 

Genbank Nucleotide ID

 AAA52017.1; AAA52018.1; AAB53685.1; AAB53685.1; AAB53685.1; AAB53685.1; AAB53685.1; AAB53685.1; AAB53685.1; AAB53685.1; AAP35515.1; BAD97101.1; BAG36496.1; EAW81505.1; AAH01059.1; AAH06459.1; AAH09384.2; AAH12755.2 

Protein Name

 Chromogranin-A 

Protein Synonyms/Alias

 CgA; Pituitary secretory protein I; SP-I; Vasostatin-1; Vasostatin I; Vasostatin-2; Vasostatin II; EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37 

Gene Name

 CHGA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	DLALQGAKERAHQQK	ubiquitination	[1]
373	DNRDSSMKLSFRARA	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. 

Sequence Annotation

 REGION 41 59 O-glycosylated at one site only in
 REGION 181 191 O-glycosylated at one site only in
 MOD_RES 142 142 Phosphoserine (By similarity).
 MOD_RES 194 194 Phosphotyrosine (By similarity).
 MOD_RES 203 203 Phosphoserine.
 MOD_RES 218 218 Phosphoserine.
 MOD_RES 270 270 Phosphoserine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 319 319 Glycine amide.
 MOD_RES 322 322 Phosphoserine.
 MOD_RES 333 333 Phosphoserine.
 MOD_RES 398 398 Phosphoserine (By similarity).
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 456 456 Arginine amide.
 CARBOHYD 181 181 O-linked (GalNAc...).
 CARBOHYD 183 183 O-linked (GalNAc...).
 CARBOHYD 251 251 O-linked (GalNAc...).
 DISULFID 35 56  

Keyword

 3D-structure; Amidation; Calcium; Cleavage on pair of basic residues; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Sulfation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 457 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0030141; C:secretory granule; IEA:InterPro.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0008217; P:regulation of blood pressure; TAS:ProtInc. 

Interpro

 IPR001819; Chromogranin_AB.
 IPR018054; Chromogranin_CS.
 IPR001990; Granin. 

Pfam

 PF01271; Granin 

SMART

  

PROSITE

 PS00422; GRANINS_1
 PS00423; GRANINS_2 

PRINTS

 PR00659; CHROMOGRANIN.