UniProt Accession

 CENPQ_HUMAN; Q7L2Z9; A8KAF1; Q6IN61; Q9NVS5 

Genbank Protein ID

 AK001407; AK293016; AL590244; AL590668; AL590668; AL590244; BC016279 

Genbank Nucleotide ID

 BAA91672.1; BAF85705.1; CAI13088.1; CAI13088.1; CAI14313.1; CAI14313.1; AAH16279.2 

Protein Name

 Centromere protein Q 

Protein Synonyms/Alias

 CENP-Q 

Gene Name

 CENPQ 

Gene Synonyms/Alias

 C6orf139 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	KKNKNHLKDLSSEGQ	ubiquitination	[1]
56	LSSEGQTKHTNLKHG	ubiquitination	[1, 2]
78	KTWQPLSKSTRDHLQ	ubiquitination	[3, 4]
180	TGNIQSLKNKIQILA	ubiquitination	[5]
182	NIQSLKNKIQILASE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. 

Sequence Annotation

 MOD_RES 31 31 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.
 MOD_RES 249 249 Phosphoserine.  

Keyword

 Centromere; Chromosome; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 268 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 

Interpro

 IPR025212; CAD_CENP-Q. 

Pfam

 PF13094; CENP-Q 

SMART

  

PROSITE

  

PRINTS