UniProt Accession

 DESI2_HUMAN; Q9BSY9; B1APK6; Q5VVC6; Q9NYS2; Q9Y3E4 

Genbank Protein ID

 AF229834; AF151904; AL451007; AC099757; AL451007; AC099757; CH471148; CH471148; BC004485 

Genbank Nucleotide ID

 AAF42919.1; AAD34141.1; CAH70879.1; CAH70879.1; CAH70880.1; CAH70880.1; EAW77114.1; EAW77116.1; AAH04485.1 

Protein Name

 Desumoylating isopeptidase 2 

Protein Synonyms/Alias

 DeSI-2; PPPDE peptidase domain-containing protein 1; Protein FAM152A 

Gene Name

 DESI2 

Gene Synonyms/Alias

 C1orf121; FAM152A; PPPDE1; CGI-146; PNAS-4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	EELGKEYKGNAYHLM	ubiquitination	[1]
122	LSEILCGKEIPRWIN	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protease which may deconjugate SUMO from some substrate proteins (By similarity). 

Sequence Annotation

 DOMAIN 5 149 PPPDE peptidase.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR008580; DUF862_euk. 

Pfam

 PF05903; DUF862 

SMART

  

PROSITE

  

PRINTS