CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016149
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Longitudinals lacking protein, isoforms F/I/K/T 
Protein Synonyms/Alias
  
Gene Name
 lola 
Gene Synonyms/Alias
 CG12052 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
677NVQLADSKPIASRIRacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo. 
Sequence Annotation
 DOMAIN 32 97 BTB.
 ZN_FING 903 925 C2H2-type 1; degenerate.
 ZN_FING 933 955 C2H2-type 2.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Differentiation; DNA-binding; Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 970 AA 
Protein Sequence
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL 60
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQASKQDK GEQTEGAQDE FELDDCLLES 480
NDIVITQNKD GFVLHVKKLG NITAAKLEEN QAVAQQQGQA AVTVTGPAGQ PTPTITELLN 540
AAAASHSEPK PTLTTLTSTP IKLPSSECEL INIKKIIPAT TTIATHHPHT SSTIIHPHHI 600
IQHVSQEPHH QEHHQQHQTI HIEEVPQTSQ QHHQQQHHHQ LQTVQPTHTQ VQSIITAHPG 660
QTINLVGLRN VQLADSKPIA SRIRYSRGKI IGPTVQNLQI VETHEPIQHQ HHELSDGTKY 720
EISEIDLNNP NASAAIISDL VKYAEIDDIE LPDGTKIGIG FAPSEITEHM QTSGGETHIT 780
TIEHEPQELQ TVHQHEQTQQ THHIHAGQLQ THHIQTVVQS SSGQQQHDQQ QHHQHHSIEL 840
QDDDGVETIT PEELGMHDSS KSYTILTTRP MKEESEHDPS GMTYELSLSD SSLGPCDDPE 900
SRYVCRHCGK KYRWKSTLRR HENVECGGKE PCHPCPYCSY KAKQRGNLGV HVRKHHPEKP 960
QLESKRGRKV 970 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
 GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
 GO:0048854; P:brain morphogenesis; IMP:FlyBase.
 GO:0008406; P:gonad development; IMP:FlyBase.
 GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.
 GO:0031987; P:locomotion involved in locomotory behavior; IMP:FlyBase.
 GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0045467; P:R7 cell development; IMP:FlyBase.
 GO:0001964; P:startle response; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB
 PF00096; zf-C2H2 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS