CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RING finger protein 10 
Protein Synonyms/Alias
  
Gene Name
 RNF10 
Gene Synonyms/Alias
 KIAA0262; RIE2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49AGPAGESKPKSDGKNubiquitination[1]
73KRELSYPKNESFNNQubiquitination[1]
105QRGGGSSKLFSSSFNubiquitination[1]
136PAQFSGPKKINLNHLubiquitination[1]
137AQFSGPKKINLNHLLubiquitination[1]
311LVALPKSKWMNVDHPubiquitination[1]
337SKLLLASKEQVLHRVubiquitination[1]
349HRVVLEEKVALEQQLubiquitination[1]
376EAAIQELKTREEALSubiquitination[1]
499SQQEPITKSGFTRLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral nerve development and Schawnn cell differentiation (By similarity). 
Sequence Annotation
 ZN_FING 225 267 RING-type.
 REGION 101 185 Interaction with MEOX2.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 811 AA 
Protein Sequence
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS 60
KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA 120
EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL 180
FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC 240
GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE 300
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK 360
HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKSL 420
LQQGVLEYLS AFDEETTEVC SLDTPSRPLA LPLVEEEEAV SEPEPEGLPE ACDDLELADD 480
NLKEGTICTE SSQQEPITKS GFTRLSSSPC YYFYQAEDGQ HMFLHPVNVR CLVREYGSLE 540
RSPEKISATV VEIAGYSMSE DVRQRHRYLS HLPLTCEFSI CELALQPPVV SKETLEMFSD 600
DIEKRKRQRQ KKAREERRRE RRIEIEENKK QGKYPEVHIP LENLQQFPAF NSYTCSSDSA 660
LGPTSTEGHG ALSISPLSRS PGSHADFLLT PLSPTASQGS PSFCVGSLEE DSPFPSFAQM 720
LRVGKAKADV WPKTAPKKDE NSLVPPAPVD SDGESDNSDR VPVPSFQNSF SQAIEAAFMK 780
LDTPATSDPL SEEKGGKKRK KQKQKLLFST SVVHTK 816 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010626; P:negative regulation of Schwann cell proliferation; ISS:UniProtKB.
 GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS