| Tag | Content |
|---|
| CPLM ID | CPLM-007586 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Megakaryocyte-associated tyrosine-protein kinase |
Protein Synonyms/Alias | CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK |
Gene Name | MATK |
Gene Synonyms/Alias | CTK; HYL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | EALSADPKLSLMPWF | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. |
Sequence Annotation | DOMAIN 58 110 SH3.
DOMAIN 122 211 SH2.
DOMAIN 235 482 Protein kinase.
NP_BIND 241 249 ATP (By similarity).
ACT_SITE 352 352 Proton acceptor (By similarity).
BINDING 262 262 ATP (By similarity).
MOD_RES 501 501 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 507 AA |
Protein Sequence | MQGHFPAERR EGRPRRGTRG QQQLLVSPRF LRAWHPPPVS ARMPTRRWAP GTQCITKCEH 60
TRPKPGELAF RKGDVVTILE ACENKSWYRV KHHTSGQEGL LAAGALRERE ALSADPKLSL 120
MPWFHGKISG QEAVQQLQPP EDGLFLVRES ARHPGDYVLC VSFGRDVIHY RVLHRDGHLT 180
IDEAVFFCNL MDMVEHYSKD KGAICTKLVR PKRKHGTKSA EEELARAGWL LNLQHLTLGA 240
QIGEGEFGAV LQGEYLGQKV AVKNIKCDVT AQAFLDETAV MTKMQHENLV RLLGVILHQG 300
LYIVMEHVSK GNLVNFLRTR GRALVNTAQL LQFSLHVAEG MEYLESKKLV HRDLAARNIL 360
VSEDLVAKVS DFGLAKAERK GLDSSRLPVK WTAPEALKHG KFTSKSDVWS FGVLLWEVFS 420
YGRAPYPKMS LKEVSEAVEK GYRMEPPEGC PGPVHVLMSS CWEAEPARRP PFRKLAEKLA 480
RELRSAGAPA SVSGQDADGS TSPRSQEP 508 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:HPA. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. GO:0004713; F:protein tyrosine kinase activity; TAS:ProtInc. GO:0008283; P:cell proliferation; TAS:ProtInc. GO:0007498; P:mesoderm development; TAS:ProtInc. GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |