CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative cyclic di-GMP phosphodiesterase YliE 
Protein Synonyms/Alias
  
Gene Name
 yliE 
Gene Synonyms/Alias
 b0833; JW0817 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
775MPFSAWDKSGKLVKEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. 
Sequence Annotation
 DOMAIN 527 781 EAL.  
Keyword
 c-di-GMP; Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 782 AA 
Protein Sequence
MLSLYEKIKI RLIILFLLAA LSFIGLFFII NYQLVSERAV KRADSRFELI QKNVGYFFKD 60
IERSALTLKD SLYLLKNTEE IQRAVILKME MMPFLDSVGL VLDDNKYYLF SRRANDKIVV 120
YHQEQVNGPL VDESGRVIFA DFNPSKRPWS VASDDSNNSW NPAYNCFDRP GKKCISFTLH 180
INGKDHDLLA VDKIHVDLNW RYLNEYLDQI SANDEVLFLK QGHEIIAKNQ LAREKLIIYN 240
SEGNYNIIDS VDTEYIEKTS AVPNNALFEI YFYYPGGNLL NASDKLFYLP FAFIIIVLLV 300
VYLMTTRVFR RQFSEMTELV NTLAFLPDST DQIEALKIRE GDAKEIISIK NSIAEMKDAE 360
IERSNKLLSL ISYDQESGFI KNMAIIESNN NQYLAVGIIK LCGLEAVEAV FGVDERNKIV 420
RKLCQRIAEK YAQCCDIVTF NADLYLLLCR ENVQTFTRKI AMVNDFDSSF GYRNLRIHKS 480
AICEPLQGEN AWSYAEKLKL AISSIRDHMF SEFIFCDDAK LNEIEENIWI ARNIRHAMEI 540
GELFLVYQPI VDINTRAILG AEALCRWVSA ERGIISPLKF ITIAEDIGFI NELGYQIIKT 600
AMGEFRHFSQ RASLKDDFLL HINVSPWQLN EPHFHERFTT IMKENGLKAN SLCVEITETV 660
IERINEHFYL NIEQLRKQGV RISIDDFGTG LSNLKRFYEI NPDSIKVDSQ FTGDIFGTAG 720
KIVRIIFDLA RYNRIPVIAE GVESEDVARE LIKLGCVQAQ GYLYQKPMPF SAWDKSGKLV 780
KE 782 
Gene Ontology
 GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IEA:EC. 
Interpro
 IPR001633; Diguanylate_PEstase_EAL_dom. 
Pfam
 PF00563; EAL 
SMART
 SM00052; EAL 
PROSITE
 PS50883; EAL 
PRINTS