CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004877
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Choline kinase 
Protein Synonyms/Alias
  
Gene Name
 CKI1 
Gene Synonyms/Alias
 CKI; YLR133W; L3130; L9606.8 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
454SHLRGGAKEPIDEEVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline. 
Sequence Annotation
 MOD_RES 30 30 Phosphoserine; by PKA.
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 54 54 Phosphothreonine.
 MOD_RES 85 85 Phosphoserine; by PKA.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
MVQESRPGSV RSYSVGYQAR SRSSSQRRHS LTRQRSSQRL IRTISIESDV SNITDDDDLR 60
AVNEGVAGVQ LDVSETANKG PRRASATDVT DSLGSTSSEY IEIPFVKETL DASLPSDYLK 120
QDILNLIQSL KISKWYNNKK IQPVAQDMNL VKISGAMTNA IFKVEYPKLP SLLLRIYGPN 180
IDNIIDREYE LQILARLSLK NIGPSLYGCF VNGRFEQFLE NSKTLTKDDI RNWKNSQRIA 240
RRMKELHVGV PLLSSERKNG SACWQKINQW LRTIEKVDQW VGDPKNIENS LLCENWSKFM 300
DIVDRYHKWL ISQEQGIEQV NKNLIFCHND AQYGNLLFTA PVMNTPSLYT APSSTSLTSQ 360
SSSLFPSSSN VIVDDIINPP KQEQSQDSKL VVIDFEYAGA NPAAYDLANH LSEWMYDYNN 420
AKAPHQCHAD RYPDKEQVLN FLYSYVSHLR GGAKEPIDEE VQRLYKSIIQ WRPTVQLFWS 480
LWAILQSGKL EKKEASTAIT REEIGPNGKK YIIKTEPESP EEDFVENDDE PEAGVSIDTF 540
DYMAYGRDKI AVFWGDLIGL GIITEEECKN FSSFKFLDTS YL 582 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004103; F:choline kinase activity; IDA:SGD.
 GO:0004305; F:ethanolamine kinase activity; IMP:SGD.
 GO:0006646; P:phosphatidylethanolamine biosynthetic process; IMP:SGD. 
Interpro
 IPR026712; Cho/Etha_kinase.
 IPR007521; Choline_kin_N.
 IPR011009; Kinase-like_dom. 
Pfam
 PF04428; Choline_kin_N 
SMART
  
PROSITE
  
PRINTS