UniProt Accession

 MPP6_MOUSE; Q9JLB0; Q9JLB1; Q9WV37 

Genbank Protein ID

 AF199009; AF199010; AF161181 

Genbank Nucleotide ID

 AAF63790.1; AAF63791.1; AAD45009.1 

Protein Name

 MAGUK p55 subfamily member 6 

Protein Synonyms/Alias

 Dlgh4 protein; P55T protein; Protein associated with Lin-7 2 

Gene Name

 Mpp6 

Gene Synonyms/Alias

 Dlgh4; Pals2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
416	EADIKAGKYLEHGEY	ubiquitination	[1, 2]
482	ETLRAMHKAVVDAGI	ubiquitination	[3]
528	IVNDNLDKAFEKLQT	ubiquitination	[3]
532	NLDKAFEKLQTAIEK	ubiquitination	[3]
539	KLQTAIEKLRMEPQW	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 DOMAIN 1 48 L27 1.
 DOMAIN 49 107 L27 2.
 DOMAIN 129 208 PDZ.
 DOMAIN 228 297 SH3.
 DOMAIN 351 538 Guanylate kinase-like.
 MOD_RES 513 513 Phosphotyrosine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 553 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISS:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0004385; F:guanylate kinase activity; ISS:MGI. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR004172; L27.
 IPR014775; L27_C.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00625; Guanylate_kin
 PF02828; L27
 PF00595; PDZ
 PF07653; SH3_2 

SMART

 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50002; SH3 

PRINTS